B2

B2 (CAS 115687-05-3)

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Application: A cell permeable inhibitor of SIRT2 (sirtuin 2)
CAS Number: 115687-05-3
Molecular Weight: 396.8
Molecular Formula: C20H17CIN4O3
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* Refer to Certificate of Analysis for lot specific data (including water content).
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B2 is a cell permeable inhibitor of SIRT2 (sirtuin 2) (IC50 = 35 μM). B2 promotes inclusion formation in cellular models of both Huntington's disease and Parkinson's disease. B2 prevents Huntington-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity. SIRT2 is known to deacetylate histones.


References

1. Bodner, Ruth A., et al., 2006. Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases. Proceedings of the National Academy of Sciences of the United States of America. 103(11): 4246-51. PMID: 16537516

Physical State :
Solid
Solubility :
Soluble in DMSO (>5 mg/ml), water (<2 mg/ml), and ethanol (10 mM).
Storage :
Store at -20° C
Melting Point :
238.82° C (Predicted)
Boiling Point :
645.52° C at 760 mmHg (Predicted)
Density :
1.41 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
IC50 :
SIRT2: IC50 = 35 µM (human); SIRT3: IC50 = >50 µM (human); SIRT1: IC50 = >50 µM (human)
pK Values :
pKb: 2.31 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
3953303
MDL Number :
MFCD02039810
SMILES :
C1CN(CCN1C2=C3C=CC=NC3=C(C=C2)[N+](=O)[O-])C(=O)C4=CC=C(C=C4)Cl

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Certificate of Analysis

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