Autophagy Inhibitor, 3-MA is a synthetic intermediate and a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis post serum/potassium deprivation. Autophagy Inhibitor, 3-MA is a PI 3-kinase p100 (class III PI 3-kinase inhibitor) that displays distinctly different properties from the PI 3-kinase inhibitors LY 294002 (sc-201426) and Wortmannin (sc-3505), in that treatment of cells with 3-MA results in specific redistribution of mannose 6-phosphate/insulin-like growth factor II receptor (MPR300), but does not cause the enlargement of late endosomal/lysosomal compartments. Autophagy Inhibitor, 3-MA is also an inhibitor of PI 3-kinase p110 γ.
1. Caro, L.H., et al. 1988. Eur. J. Biochem. 175: 325-329. PMID: 3402459
2. Eskelinen, E.L., et al. 2002. Traffic. 3: 878-893. PMID: 12453151
3. Beugnet, A., et al. 2003. Biochem. J. 372: 555-566. PMID: 12611592
4. Hirosako, K., et al. 2004. Biochem. Biophys. Res. Commun. 316: 845-852. PMID: 15033478
5. Canu, N., et al. 2005. J. Neurochem. 92: 1228-1242. PMID: 15715672
See how others have used Autophagy Inhibitor, 3-MA. Click on the entry to view the PubMed entry .
PMID: # 28499910
Aseer, KR. et al. 2017. SPARC paucity alleviates superoxide-mediated oxidative stress, apoptosis, and autophagy in diabetogenic hepatocytes. Free Radic. Biol. Med.. 108: 874-895.
PMID: # 26031379
Sun, L. et al. 2015. A novel cognitive impairment mechanism that astrocytic p-connexin 43 promotes neuronic autophagy via activation of P2X7R and down-regulation of GLT-1 expression in the hippocampus following traumatic brain injury in rats. Behav. Brain Res.. 291: 315-24.
PMID: # 26486079
2015. CGK733-induced LC3 II formation is positively associated with the expression of cyclin-dependent kinase inhibitor p21Waf1/Cip1 through modulation of the AMPK and PERK/CHOP signaling pathways. Oncotarget. 6: 39692-701.
PMID: # 26316755
Cai, Z. et al. 2015. Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex. Neuropsychiatr Dis Treat. 11: 2091-9.
PMID: # 26338963
Granato, M. et al. 2015. Capsaicin triggers immunogenic PEL cell death, stimulates DCs and reverts PEL-induced immune suppression. Oncotarget. 6: 29543-54.
PMID: # 26360292
Rodríguez, CE. et al. 2015. Autophagy Protects from Trastuzumab-Induced Cytotoxicity in HER2 Overexpressing Breast Tumor Spheroids. PloS one. 10: e0137920.
PMID: # 26592514
Liu, GY. et al. 2015. ROS activates JNK-mediated autophagy to counteract apoptosis in mouse mesenchymal stem cells in vitro. Acta Pharmacol. Sin.. 36: 1473-9.
PMID: # 25318653
Gao, L. et al. 2015. Excessive autophagy induces the failure of trophoblast invasion and vasculature: possible relevance to the pathogenesis of preeclampsia. J. Hypertens.. 33: 106-17.
PMID: # 25609235
Kanayama, M. et al. 2015. Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity. Nature communications. 6: 5779.
PMID: # 26373839
Miyazaki, S. et al. 2015. Recombinant human SIRT1 protects against nutrient deprivation-induced mitochondrial apoptosis through autophagy induction in human intervertebral disc nucleus pulposus cells. Arthritis Res. Ther.. 17: 253.
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