Autophagy Inhibitor, 3-MA is a synthetic intermediate and a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis post serum/potassium deprivation. Autophagy Inhibitor, 3-MA is a PI 3-kinase p100 (class III PI 3-kinase inhibitor) that displays distinctly different properties from the PI 3-kinase inhibitors LY 294002 (sc-201426) and Wortmannin (sc-3505), in that treatment of cells with 3-MA results in specific redistribution of mannose 6-phosphate/insulin-like growth factor II receptor (MPR300), but does not cause the enlargement of late endosomal/lysosomal compartments. Autophagy Inhibitor, 3-MA is also an inhibitor of PI 3-kinase p110 γ.
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