Autophagy Inhibitor, 3-MA Autophagy Inhibitor, 3-MA is a cell-permeable autophagic sequestration blocker. It is also a class III PI 3-kinase inhibitor that displays distinctly different properties from LY 294002 (sc-201426) and Wortmannin (sc-3505).

Autophagy Inhibitor, 3-MA  (CAS 5142-23-4)

Autophagy Inhibitor, 3-MA is rated 5.0 out of 5 by 1.
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| See 23 Citations
Synonym: 3-methyladenine
Application: A multi-use inhibitor that protects cerebellar granule cells from apoptosis
CAS Number: 5142-23-4
Purity: ≥95%
Molecular Weight: 149.15
Molecular Formula: C6H7N5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Autophagy Inhibitor, 3-MA sc-205596 50 mg $89.00
Autophagy Inhibitor, 3-MA sc-205596A 500 mg $468.00

Autophagy Inhibitor, 3-MA is a synthetic intermediate and a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis post serum/potassium deprivation. Autophagy Inhibitor, 3-MA is a PI 3-kinase p100 (class III PI 3-kinase inhibitor) that displays distinctly different properties from the PI 3-kinase inhibitors LY 294002 (sc-201426) and Wortmannin (sc-3505), in that treatment of cells with 3-MA results in specific redistribution of mannose 6-phosphate/insulin-like growth factor II receptor (MPR300), but does not cause the enlargement of late endosomal/lysosomal compartments. Autophagy Inhibitor, 3-MA is also an inhibitor of PI 3-kinase p110 γ.


References

1. Caro, L.H., et al. 1988. Eur. J. Biochem. 175: 325-329. PMID: 3402459
2. Eskelinen, E.L., et al. 2002. Traffic. 3: 878-893. PMID: 12453151
3. Beugnet, A., et al. 2003. Biochem. J. 372: 555-566. PMID: 12611592
4. Hirosako, K., et al. 2004. Biochem. Biophys. Res. Commun. 316: 845-852. PMID: 15033478
5. Canu, N., et al. 2005. J. Neurochem. 92: 1228-1242. PMID: 15715672

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml), water (5 mg/ml), DMF (10 mg/ml), 95% ethanol, and 1N NaOH heating (30 mg/ml).
Storage :
Store at 4° C
Melting Point :
300° C (lit.)(dec.)
Boiling Point :
240° C
Density :
1.6 g/cm3
Refractive Index :
n20D 1.81 (Predicted)
IC50 :
class III PI3K: IC50 = 4.5 mM
pK Values :
pKb: 6.77 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
AU6520000
PubChem CID :
1673
MDL Number :
MFCD00010531
EC Number :
225-908-6
Beilstein Registry :
146087
SMILES :
CN1C=NC(=C2C1=NC=N2)N

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Autophagy Inhibitor, 3-MA Product Citations

See how others have used Autophagy Inhibitor, 3-MA. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 23 total

PMID: # 26031379
Sun, L. et al. 2015. A novel cognitive impairment mechanism that astrocytic p-connexin 43 promotes neuronic autophagy via activation of P2X7R and down-regulation of GLT-1 expression in the hippocampus following traumatic brain injury in rats. Behav. Brain Res.. 291: 315-24.

PMID: # 26360292
Rodríguez, CE. et al. 2015. Autophagy Protects from Trastuzumab-Induced Cytotoxicity in HER2 Overexpressing Breast Tumor Spheroids. PloS one. 10: e0137920.

PMID: # 26592514
Liu, GY. et al. 2015. ROS activates JNK-mediated autophagy to counteract apoptosis in mouse mesenchymal stem cells in vitro. Acta Pharmacol. Sin.. 36: 1473-9.

PMID: # 25609235
Kanayama, M. et al. 2015. Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity. Nature communications. 6: 5779.

PMID: # 26316755
Cai, Z. et al. 2015. Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex. Neuropsychiatr Dis Treat. 11: 2091-9.

PMID: # 25596736
Zhang, J. et al. 2015. P62 regulates resveratrol-mediated Fas/Cav-1 complex formation and transition from autophagy to apoptosis. Oncotarget. 6: 789-801.

PMID: # 26373839
Miyazaki, S. et al. 2015. Recombinant human SIRT1 protects against nutrient deprivation-induced mitochondrial apoptosis through autophagy induction in human intervertebral disc nucleus pulposus cells. Arthritis Res. Ther.. 17: 253.

PMID: # 26188042
Chow, WN. et al. 2015. Phosphorylation of FE65 Ser610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing. Biochem. J.. 470: 303-17.

PMID: # 23831571
He, W. et al. 2014. A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy. Oncogene. 33: 3004-3013.

PMID: # 25310356
Guo, N. et al. 2014. Berberine sensitizes rapamycin-mediated human hepatoma cell death in vitro. Mol Med Rep. 10: 3132-8.

Citations 1 to 10 of 23 total
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Rated 5 out of 5 by from Canu et al Canu et al. (PubMed ID 15715672) used autophagy inhibitor, 3-MA, to induce apoptosis in cultured cerebellar granule cells by blocking cytochrome C. -SCBT Publication Review
Date published: 2015-05-21
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