Autocamtide-2 Peptide A highly selective peptide substrate for CaM Kinase II

Autocamtide-2 Peptide

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Synonym: KKALRRQETVDAL; Calcium/calmodulin-dependent protein kinase type II alpha chain; KIAA0968
Application: A highly selective peptide substrate for CaM Kinase II
Purity: ≥95%
Molecular Weight: 1527.8
Molecular Formula: C65H118N22O20
* Refer to Certificate of Analysis for lot specific data (including water content).
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Autocamtide-2 Peptide is a highly selective peptide substrate for calcium/calmodulin-dependent protein kinase II (CaMKII), a member of the CAMK Ser/Thr protein kinase family. The Autocamtide-2 Peptide sequence (KKALRRQETVDAL) is based on the autophosphorylation site (aa 283-290) on CaM Kinase II. CaMKII is a prominent kinase in the central nervous system that functions in long-term potentiation and neurotransmitter release. Autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state.


References

1. Jones, P M., et al., 1998. Ca(2+)-induced loss of Ca2+/calmodulin-dependent protein kinase II activity in pancreatic beta-cells. The American journal of physiology. 274(4 Pt 1): E708-15. PMID: 9575833
2. Blair, R E., et al., 1999. Long-lasting decrease in neuronal Ca2+/calmodulin-dependent protein kinase II activity in a hippocampal neuronal culture model of spontaneous recurrent seizures. Brain research. 851(1-2): 54-65. PMID: 10642828
3. Takano, Hiromichi., et al., 2003. Calmodulin and calmodulin-dependent kinase II mediate neuronal cell death induced by depolarization. Brain research. 962(1-2): 41-7. PMID: 12543454

Usage :
Reconstitution: Dilute peptide in distilled H2O to a final concentration of 1mg/ml.


Store at -20°C. For long term storage, aliquot
diluted product into smaller quantities and store at
recommended temperature. Avoid repeated handling and multiple freeze/thaw cycles.
Physical State :
Solid
Sequence :
Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu
Solubility :
Soluble in water (1 mg/ml).
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Download SDS (MSDS)

Certificate of Analysis

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