Aurodox inhibits bacterial protein biosynthesis by interrupting the functional cycle of Elongation Factor-Tu (EF-Tu). This is a weakly acidic antibiotic that causes a ribosomal stoppage during translation.
Feedback inhibition of the synthesis of an antibiotic: aurodox (X-5108).: C. Liu, et al.; J. Antibiot. 30, 244 (1977) Increased production of the antibiotic aurodox (X-5108) by aurodox-resistant mutants.: J. Unowsky & D.C. Hoppe; J. Antibiot. 31, 662 (1978) Stimulation of Escherichia coli elongation factor Tu-dependent GTP hydrolysis by aminoacyl oligonucleotides in the presence of aurodox.: P. Bhuta & S. Chladek; FEBS Lett. 122, 113 (1980) Synthetic analogs of aurodox and kirromycin active on elongation factor Tu from Escherichia coli.: G. Chinali; J. Antibiot. 34, 1039 (1981) Effects of nucleotide- and aurodox-induced changes in elongation factor Tu conformation upon its interactions with aminoacyl transfer RNA. A fluorescence study.: V.A. Dell, et al.; Biochemistry 29, 1757 (1990) Conformational change of elongation factor Tu (EF-Tu) induced by antibiotic binding. Crystal structure of the complex between EF-Tu.GDP and aurodox.: L. Vogeley, et al.; J. Biol. Chem. 276, 17149 (2001)
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