Aurintricarboxylic Acid a cell-permeable polyanionic, polyaromatic compound employed as a powerful inhibitor of cellular processes, including apoptosis, that are dependent on the formation of protein-nucleic acid complexes. It binds to a FGF and reduces its angiogenic activity. Aurintricarboxylic Acid has been shown to inhibit apoptotic cell death in various cell types induced by a variety of factors. It has also been demonstrated to be a potent inhibitor of DNA topoisomerase II (IC50= 75 nM for the yeast enzyme as measured by relaxation assays) that inhibits angiogenesis. Aurintricarboxylic Acid inhibits von Willebrand factor binding to platelets and reduces glutamate-induced neuronal injury. Aurintricarboxylic Acid also stimulates the tyrosine phosphorylation of MAP kinases, Shc proteins, phosphatidylinositol 3-kinase, and phospholipase Cγ and inhibits both major calpain isoforms (IC50 = 22 µM and IC50 = 10 μM for μ-calpain and m-calpain, respectively).
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Soluble in water (7 mg/mL), 1 M NH4OH (10 mg/mL), ethanol (60 mg/mL), 0.1 M NaOH (35 mg/mL), and aqueous alkali.
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