AST 1306 is a potent(pM) and selective inhibitor of EGFR and ErbB4 (IC50 = 500pM and 800 pM, respectively). AST 1306 blocks phosphorylation of EGFR and also prevents downstream pathways. AST 1306 also dose-dependently inhibits EGF-induced EGFR phosphorylation in the A549 cancer cell line.
1. Xie H, et al. PLoS One. 2011, 6(7), e21487.
Soluble in DMSO (124 mg/mL at 25 °C), water (<1 mg/mL at 25 °C), and ethanol (<1 mg/mL at 25 °C). Insoluble in 0.5% hydroxyethyl cellulose.
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