ASB-C7BzO A zwitterionic detergent

ASB-C7BzO

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Synonym: 3-(4-Heptyl)phenyl-3-hydroxypropyl)dimethylammoniopropanesulfonate
Application: A zwitterionic detergent
Molecular Weight: 399.6
Molecular Formula: C21H37NO4S
* Refer to Certificate of Analysis for lot specific data (including water content).
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ASB-C7BzO is a zwitterionic detergent which contains hydroxypropyl group between alkylphenyl hydrophobic tail and ammonio-propane sulfone hydrophilic head. Useful for solubilizing and stabilizing integral membrane proteins by disrupting aggregates. ASB-C7BzO is reported to be compatible with urea (~7 M) and has been used successfully to extract A. thaliana leaf plasma membrane proteins and band III, a 100 kDa erythrocyte polytransmembrane protein, by two-dimensional electrophoresis (2-DGE).


References

1. Rabilloud, T., et al., 1999. Analysis of membrane proteins by two-dimensional electrophoresis: comparison of the proteins extracted from normal or Plasmodium falciparum-infected erythrocyte ghosts. Electrophoresis. 20(18): 3603-10. PMID: 10612287
2. Tastet, Christophe., et al., 2003. Structure-efficiency relationships of zwitterionic detergents as protein solubilizers in two-dimensional electrophoresis. Proteomics. 3(2): 111-21. PMID: 12601803
3. Luche, Sylvie., et al., 2003. Evaluation of nonionic and zwitterionic detergents as membrane protein solubilizers in two-dimensional electrophoresis. Proteomics. 3(3): 249-53. PMID: 12627377

Physical State :
Solid
Solubility :
Soluble in water
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11951796
SMILES :
CCCCCCCC1=CC=C(C=C1)C(CC[N+](C)(C)CCCS(=O)(=O)[O-])O

Download SDS (MSDS)

Certificate of Analysis

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