Artemisinin An antimalarial agent that inhibits VEGF expression and NOS2

Artemisinin (CAS 63968-64-9)

Artemisinin | CAS 63968-64-9 is rated 5.0 out of 5 by 1.
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Synonym: Arteannuin; Qinghaosu
Application: An antimalarial agent that inhibits VEGF expression and NOS2
CAS Number: 63968-64-9
Purity: >98%
Molecular Weight: 282.33
Molecular Formula: C15H22O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Artemisinin is a powerful antimalarial agent. Artemisinin inhibits angiogenesis by down-regulating HIF-1α and VEGF expression in mouse embryonic stem cells. Artemisinin crosses the blood-brain barrier and is an inhibitor of human NOS2 (iNOS).


References

Qinghaosu (artemisinin): an antimalarial drug from China: D.L. Klayman; Science 228, 1049 (1985) The chemistry, pharmacology, and clinical applications of qinghaosu (artemisinin) and its derivatives: X.D. Luo & C.C. Shen; Med. Res. Rev. 7, 29 (1987) Inhibition of angiogenesis in embryoid bodies by artemisinin: M. Wartenberg, et al.; Pflugers Arch. Eur. J. Physiol. 445, S85 (1994) Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medication: M.A. van Agtmael, et al.; Trends Pharmacol. Sci. 20, 199 (1999), Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation: E. Aldieri, et al.; FEBS Lett. 552, 141 (2003) The antimalaria agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies: M. Wartenberg, et al.; Lab. Invest. 83, 1647 (2003) An over four millennium story behind qinghaosu (artemisinin)--a fantastic antimalarial drug from a traditional chinese herb: Y. Li & Y.L. Wu; Curr. Med. Chem. 10, 2197 (2003), From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements: R.K. Haynes; Curr. Top. Med. Chem. 6, 509 (2006)

Physical State :
Solid
Derived From :
Artemisia annua L. (traditional Chinese anti-malarial herb)
Solubility :
Soluble in methanol, ethanol (24 mg/ml) at 25° C, DMF, DMSO (57 mg/ml) at 25° C, acetone, chloroform (25 mg/ml), dichloromethane, and ethyl acetate; almost insoluble in water.
Storage :
Store at -20° C
Melting Point :
156-157° C (lit.)
Boiling Point :
389.90° C at 760 mmHg (Predicted)
Density :
1.25 g/cm3 (Predicted)
Refractive Index :
n20D 1.53 (Predicted)
Optical Activity :
α20/D +76°, c = 0.5 in methanol
IC50 :
Plasmodium falciparum: IC50 = 1 nM; Plasmodium falciparum K1: IC50 = 2.8 nM; LLC-PK1: IC50 = 2.12 µM (pig); Filobasidiella neoformans: IC50 = 7.08 µM; Toxoplasma gondii: IC50 = 8.14 µM
Ki Data :
PfATP6: Ki= ~ 150 nM (Plasmodium falciparum)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
KD4170000
PubChem CID :
452191
Merck Index :
14: 817
MDL Number :
MFCD00081057
Beilstein Registry :
4194670
SMILES :
C[C@@H]1CC[C@H]2[C@H](C(=O)O[C@H]3[C@@]24[C@H]1CCC(O3)(OO4)C)C

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Artemisinin  Product Citations

See how others have used Artemisinin. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 23229489  Mahanty, S. et al. 2013. Antimicrob. Agents Chemother. 57: 990-5.

Citations 1 to 1 of 1 total

what dosage should i use for this raw material?

Asked by: chlps97
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Rated 5 out of 5 by from Ooko et al Ooko et al. (PubMed ID 26407947) found that artemisinin induced cytotoxic activity via ferroptosis in tumor cells. -SCBT Publication Review
Date published: 2015-01-29
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