Apoptosis Inhibitor A cell-permeable inhibitor of apoptosis induction

Apoptosis Inhibitor (CAS 54135-60-3)

Apoptosis Inhibitor | CAS 54135-60-3 is rated 5.0 out of 5 by 1.
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Application: A cell-permeable inhibitor of apoptosis induction
CAS Number: 54135-60-3
Purity: ≥95%
Molecular Weight: 236.3
Molecular Formula: C13H16O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Apoptosis Inhibitor is a cell-permeable inhibitor of apoptosis induction. It does not directly inhibit caspase-3, but effects are attributable to the inhibition of caspase-3 activation.


References

1. Tsuda, T., et al. 2001. Eur. J. Pharmacol. 433: 37-45. PMID: 11755132

Physical State :
Solid
Solubility :
Soluble in DMSO, EtOH, and water (partly miscible).
Storage :
Store at 4° C
Melting Point :
132-135° C
Boiling Point :
461.21° C at 760 mmHg (Predicted)
Density :
1.23 g/cm3 (Predicted)
Refractive Index :
n20D 1.52 (Predicted)
IC50 :
apoptosis induction: IC50 = 67 µg/ml (FasL-stimulated WC8 cells); apoptosis induction: IC50 = 130 µg/ml (etoposide-stimulated U937 cells)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
2748618
EC Number :
258-989-1
SMILES :
C1CC(=O)C(C(=O)C1)CC2C(=O)CCCC2=O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Apoptosis Inhibitor was reported as being Apoptosis Inhibitor was reported as being used as caspase-3 inhibitor in cancer applications. -SCBT Publication Review
Date published: 2015-07-10
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