Apoptosis Activator 2 is a cell-permeable indoledione compound that activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells by promoting the oligomerization of Apaf-1 into the mature apoptosome. Its cytotoxicity is selective towards tumor cells (IC50 < 10 μM for Jurkat, Molt-4, and CCRF-CEM). Apoptosis Activator 2 shows little or no effect on non-tumor cells or cells that are deficient in caspase-3 or Apaf-1. Apoptosis Activator 2 is an activator of caspase-3.
Nguyen, J.T., and Wells, J.A. 2003. Proc. Natl. Acad. Sci. USA 100, 7533.
Soluble in DMSO (5 mg/ml), methanol (5 mg/ml), and ethanol.
Store at 4° C
190.39° C (Predicted)
470.58° C at 760 mmHg (Predicted)
1.50 g/cm3 (Predicted)
n20D 1.67 (Predicted)
induces apoptosis of BT-549: IC50 = 20 µM; induces apoptosis of NCI-H23: IC50 = 35 µM; induces apoptosis of Jurkat: IC50 = 4 µM; induces apoptosis of Molt-4: IC50 = 6 µM; induces apoptosis of CCRF-CEM: IC50 = 9 µM
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