Apoptosis Activator 2 An indoledione caspase activator

Apoptosis Activator 2 (CAS 79183-19-0)

Apoptosis Activator 2 | CAS 79183-19-0 is rated 5.0 out of 5 by 1.
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Application: An indoledione caspase activator
CAS Number: 79183-19-0
Purity: >95%
Molecular Weight: 306.1
Molecular Formula: C15H9Cl2NO2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Apoptosis Activator 2 is a cell-permeable indoledione compound that activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells by promoting the oligomerization of Apaf-1 into the mature apoptosome. Its cytotoxicity is selective towards tumor cells (IC50 < 10 μM for Jurkat, Molt-4, and CCRF-CEM). Apoptosis Activator 2 shows little or no effect on non-tumor cells or cells that are deficient in caspase-3 or Apaf-1. Apoptosis Activator 2 is an activator of caspase-3.


References

Nguyen, J.T., and Wells, J.A. 2003. Proc. Natl. Acad. Sci. USA 100, 7533.

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml), methanol (5 mg/ml), and ethanol.
Storage :
Store at 4° C
Melting Point :
190.39° C (Predicted)
Boiling Point :
470.58° C at 760 mmHg (Predicted)
Density :
1.50 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
IC50 :
induces apoptosis of BT-549: IC50 = 20 µM; induces apoptosis of NCI-H23: IC50 = 35 µM; induces apoptosis of Jurkat: IC50 = 4 µM; induces apoptosis of Molt-4: IC50 = 6 µM; induces apoptosis of CCRF-CEM: IC50 = 9 µM
Ki Data :
SOAT: Ki= 31 nM (human); BChE: Ki= 12.6 µM (human); AChE: Ki= 42.8 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
1901244
MDL Number :
MFCD00141556
SMILES :
C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC(=C(C=C3)Cl)Cl

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Certificate of Analysis

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Apoptosis Activator 2  Product Citations

See how others have used Apoptosis Activator 2. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 25744026  Jia, J. et al. 2015. Cell Death Differ. 22: 1754-63.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Apoptosis Activator 2 was reported to trigger Apoptosis Activator 2 was reported to trigger apoptosis via activation of caspases in tumor cells. -SCBT Publication Review
Date published: 2015-07-01
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