Apelin-13 An endogenous ligand of the G-protein coupled receptor APJ

Apelin-13 (CAS 217082-58-1)

Apelin-13 | CAS 217082-58-1 is rated 5.0 out of 5 by 1.
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Synonym: Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
Application: An endogenous ligand of the G-protein coupled receptor APJ
CAS Number: 217082-58-1
Purity: ≥95%
Molecular Weight: 1550.83
Molecular Formula: C69H111N23O16S
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Apelin-13 is a 13 amino acid polypeptide encoded by the apelin gene which yields a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids (apelin-36, apelin-17, and apelin-13, respectively). Apelin-13 is an endogenous ligand of Apelin Receptor (APLNR/APJ receptor), a G protein-coupled receptor (EC50 = 370 μM), that plays important roles in regulating fluid homeostasis, cardiovascular function, and insulin sensitivity. Research has also shown that Apelin-36 blocks the entry of human immunodeficiency virus into cells. Apelin-13 is an activator of Apelin Receptor.


References

1. Tatemoto, K., et al. 1998. Biochem. Biophys. Res. Commun. 251: 471-476. PMID: 9792798
2. Habata, Y., et al. 1999. Biochim. Biophys. Acta. 1452: 25-35. PMID: 10525157
3. Zou, M.X., et al. 2000. FEBS Lett. 473: 15-18. PMID: 10802050
4. Lee, D.K., et al. 2000. J. Neurochem. 74: 34-41. PMID: 10617103
5. Kleinz, M.J. and Davenport, A.P. 2005. Pharmacol. Ther. 107: 198-211. PMID: 15907343

Physical State :
Solid
Sequence :
GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
Solubility :
Soluble in PBS (pH 7.2) (~10 mg/ml), ethanol (~20 mg/ml), DMSO (~30 mg/ml), and DMF (~30 mg/ml).
Storage :
Store at -20° C
Density :
1.5±0.1 g/cm3
Refractive Index :
n20D 1.69 (Predicted)
IC50 :
G protein-coupled receptor : EC5050 = 0.37 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
25078060
MDL Number :
MFCD02094627
SMILES :
CC(C)C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCSC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]5CCCN5C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N

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Apelin-13  Product Citations

See how others have used Apelin-13. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 27630697  Bao, HJ. et al. 2016. Neural Regen Res. 11: 1128-33.

PMID: # 27343409  Bao, H. et al. 2016. Neurosci. Lett. 628: 219-24.

PMID: # 26893689  Huang, Q. et al. 2016. Oncol Lett. 11: 1051-1056.

PMID: # 26924778  Zhang, NK. et al. 2016. Cell Transplant. 25: 1645-1652.

PMID: # 26631263  Yang, Y. et al. 2016. Peptides. 75: 96-100.

PMID: # 25362565  Bao, HJ. et al. 2015. Neurochem. Res. 40: 89-97.

Citations 1 to 6 of 6 total

How do I maintain Apolin-13 after solving it? maintenance condition?

Asked by: Raheleh
Thank you for your question. We don't recommend storing in solution for longer than a day.
Answered by: Tech Service
Date published: 2019-01-07

IS apelin-13 soluble in saline?Why has this article (Bao, HJ. et al. 2016. Neural Regen Res. 11: 1128-33.) dissolved Apelin in Saline?

Asked by: Raheleh
Thank you for your question. This biochemical is soluble in PBS (pH 7.2) (~10 mg/ml), ethanol (~20 mg/ml), DMSO (~30 mg/ml), and DMF (~30 mg/ml).
Answered by: Tech Service
Date published: 2019-01-07
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Rated 5 out of 5 by from Kleinz et al Kleinz et al. (PubMed ID 15907343) showed that the G-protein-coupled receptor (GPCR) APJ ligand, Apelin-13, is a strong regulator of cardiovascular function. -SCBT Publication Review
Date published: 2015-03-23
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