Apamin A potent and highly selective inhibitor of the low conductance Ca2+-activated K+ channel

Apamin (CAS 24345-16-2)

Apamin | CAS 24345-16-2 is rated 5.0 out of 5 by 1.
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Application: A potent and highly selective inhibitor of the low conductance Ca2+-activated K+ channel
CAS Number: 24345-16-2
Purity: ≥95%
Molecular Weight: 2027.34
Molecular Formula: C79H131N31O24S4
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Apamin: Caution! Highly toxic. Handle with care. The smallest neurotoxin known. It is the only polypeptide neurotoxin that is known to pass the blood-brain barrier. Comprises about 2% by weight of the dried venom of the honey bee. It is a potent (1-10 nM) and highly selective inhibitor of the SK (low conductance Ca2+-activated K+ channel). Acts on the central nervous system. SK channel blockers such as apamin can have therapeutic applications, for example on the peripheral cells (e.g. the insulin releasing cells of the pancreas) and on the central nervous system where there is evidence for a role of SK channels in memory processes, both general and specifically hippocampal.


References

1: N.A. Castle et al. Trends Neurosci. 1989 12 59 2: M. Hughes et al. Proc. Natl. Acad. Sci. USA 1982 79 1308 3: P.N. Strong Pharmacol. Therap. 1990 46 137

Appearance :
Powder
Physical State :
Solid
Sequence :
Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2
Solubility :
Soluble in acetic acid (5mg/ml) and slightly soluble in water (1mg/ml)
Storage :
Store at -20° C
Refractive Index :
n20D 1.72 (Predicted)
IC50 :
apamin-sensitive SKCa channel: IC50 = 0.001 µM (guinea-pig hepatocytes); calcium activated potassium channel: IC50 = 8.6e-06 µM
Ki Data :
[125I]apamin binding to calcium-activated potassium (SK) channel: Ki= 3.8 µM (rat cortex)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CD6899900
PubChem CID :
16218850
Merck Index :
14: 725
MDL Number :
MFCD00167944
EC Number :
246-182-7
SMILES :
C[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N3CCC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CC(=O)N)N)C(=O)N1)CC(C)C)C)[C@@H](C)O)CCC(=O)O)C)CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC4=CN=CN4)C(=O)N)CCCNC(=N)N)CCCNC(=N)N

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Certificate of Analysis

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Apamin  Product Citations

See how others have used Apamin. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 28036359  Estep, CM. et al. 2016. PLoS ONE. 11: e0169044.

PMID: # 25641660  Sung, TS. et al. 2015. J. Physiol. (Lond.). 593: 1169-81.

Citations 1 to 2 of 2 total

Is this product natural or synthetic?

Asked by: Jz28sail
Thank you for your question. sc-200994A, Apamin is a synthetic peptide.
Answered by: Chemical Support 5
Date published: 2017-04-17
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Rated 5 out of 5 by from Wang et al Wang et al. (Pubmed ID 26418566) found that apamin enhanced synaptic potentials in CaV2.3 R-Type Ca2+ Channel Null Mice. -SCBT Publication Review
Date published: 2015-06-23
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