Antimycin A3 A potent inhibitor of respiration

Antimycin A3 (CAS 522-70-3)

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Synonym: Blastmycin
Application: A potent inhibitor of respiration
CAS Number: 522-70-3
Molecular Weight: 520.57
Molecular Formula: C26H36N2O9
* Refer to Certificate of Analysis for lot specific data (including water content).
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Antimycin A3 is a homologue of the antimycin complex. Antimycin A3 is a more polar analogue of A1 and A2 and is a potent inhibitor of respiration by inhibiting the oxidation of ubiquinol to ubiquinone. Antimycin A3 exhibits broad biological activity as an antifungal, anthelmintic, insecticidal, antiviral and antitumor active.

Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in ethanol, methanol, DMF, DMSO, and water (poorly).
Storage :
Store at -20° C
Melting Point :
170° C
Boiling Point :
~745.5° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
IC50 :
Apoptosis regulator Bcl-2: IC50 = 2 µM (human)
Ki Data :
Apoptosis regulator Bcl-2: Ki= 124 µM (human); Apoptosis regulator Bcl-W: Ki= 127 µM (human); Displacement of Flu-Bak peptide from recombinant antiapoptopic Bcl-XL protein: Ki= 127 µM (human)
pK Values :
pKa: 7.28 (Predicted), pKb: 1.29 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
NY1502900
PubChem CID :
245869
MDL Number :
MFCD00869273
EC Number :
208-335-6
SMILES :
CCCC[C@@H]1[C@H]([C@@H](OC(=O)[C@H]([C@H](OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)CC(C)C

Download SDS (MSDS)

Certificate of Analysis

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