Antimycin A An antibiotic that induces apoptosis

Antimycin A (CAS 1397-94-0)

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Synonym: Antipiricullin; Virosin
Application: An antibiotic that induces apoptosis
CAS Number: 1397-94-0
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Antimycin A is an antibiotic that induces apoptosis and inhibits the mitochondrial electron transport chain from cytochrome b to cytochrome C1. Additionally, studies report that antimycin A causes damage to mitochondrial DNA, lipids, and proteins in cells treated with the antibiotic. The compound has been shown to mimic cell-death-inducing Bcl-2 homology domain 3 and has been applied as a reactive oxygen species (ROS) generator to study biological systems. Research indicates that antimycin A inhibits the cell growth of HeLa cells through apoptosis and blocks nitric oxide-induced apoptosis via inhibition of cytochrome C leakage.


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Appearance :
Physical State :
Derived From :
Streptomyces sp. Mixture of antimycin A's.
Solubility :
Soluble in 100% ethanol (50 mg/ml). Insoluble in water.
Storage :
Store at -20° C
Melting Point :
162-164° C
Optical Activity :
α20/D 79°±3°, c = 0.9-1.1 in chloroform
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 714(A1) & 715 (A3)
MDL Number :

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Antimycin A  Product Citations

See how others have used Antimycin A. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 27827795  Lee, MY. et al. 2017. EMBO Rep. 18: 48-60.

PMID: # 28848034  Minowa-Nozawa, A. et al. 2017. EMBO J.

PMID: # 27091640  Wang, J. et al. 2016. Sci Rep. 6: 24641.

PMID: # 26604148  Casadei, N. et al. 2016. Hum. Mol. Genet. 25: 459-71.

PMID: # 23875533  Tsuyama, T. et al. 2013. Anal. Chem. 85: 7889-96.

Citations 1 to 5 of 5 total
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