Antimycin A An antibiotic that induces apoptosis

Antimycin A (CAS 1397-94-0)

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Synonym: Antipiricullin; Virosin
Application: An antibiotic that induces apoptosis
CAS Number: 1397-94-0
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Antimycin A is an antibiotic that induces apoptosis and inhibits the mitochondrial electron transport chain from cytochrome b to cytochrome C1. Additionally, studies report that antimycin A causes damage to mitochondrial DNA, lipids, and proteins in cells treated with the antibiotic. The compound has been shown to mimic cell-death-inducing Bcl-2 homology domain 3 and has been applied as a reactive oxygen species (ROS) generator to study biological systems. Research indicates that antimycin A inhibits the cell growth of HeLa cells through apoptosis and blocks nitric oxide-induced apoptosis via inhibition of cytochrome C leakage.


References

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2. Guidarelli, A., et al. 1996. Biochem. J. 317: 371-375. PMID: 8713060
3. Kim, K.M., et al. 2001. Biochemistry. 40: 4911-4922. PMID: 11305906
4. Tzung, S.P., et al. 2001. Nat. Cell Biol. 3: 183-191. PMID: 11175751
5. Dairaku, N., et al. 2004. J. Lab. Clin. Med. 143: 143-151. PMID: 15007303
6. Park, W.H., et al. 2007. J. Cell. Biochem. 102: 98-109. PMID: 17372917
7. Guha, G., et al. 2010. Food Chem Toxicol. PMID: 20854871

Appearance :
Powder
Physical State :
Solid
Derived From :
Streptomyces sp. Mixture of antimycin A's.
Solubility :
Soluble in 100% ethanol (50 mg/ml). Insoluble in water.
Storage :
Store at -20° C
Melting Point :
162-164° C
Optical Activity :
α20/D 79°±3°, c = 0.9-1.1 in chloroform
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CD0350000
PubChem CID :
14957
Merck Index :
14: 714(A1) & 715 (A3)
MDL Number :
MFCD01779723
SMILES :
CCCCCC[C@@H]1[C@H]([C@@H](OC(=O)[C@H]([C@H](OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)CC(C)C

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Antimycin A  Product Citations

See how others have used Antimycin A. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 27827795  Lee, MY. et al. 2017. EMBO Rep. 18: 48-60.

PMID: # 28848034  Minowa-Nozawa, A. et al. 2017. EMBO J.

PMID: # 27091640  Wang, J. et al. 2016. Sci Rep. 6: 24641.

PMID: # 26604148  Casadei, N. et al. 2016. Hum. Mol. Genet. 25: 459-71.

PMID: # 23875533  Tsuyama, T. et al. 2013. Anal. Chem. 85: 7889-96.

Citations 1 to 5 of 5 total
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