Anpirtoline hydrochloride A SR-1B agonist

Anpirtoline hydrochloride (CAS 98330-05-3)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 181ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: 2-Chloro-6-piperidin-4-ylsulfanylpyridine hydrochloride
Application: A SR-1B agonist
CAS Number: 98330-05-3
Purity: 99%
Molecular Weight: 265.20
Molecular Formula: C10H13ClN2S HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Anpirtoline hydrochloride is a selective agonist of SR-1B. Anpirtoline shows strong selectivity at SR-1B (Ki = 28 nM) over the SR-1A (Ki = 150 nM) and SR-2 (Ki = 1.49 μM) serotonin receptor subtypes. Anpirtoline is also described to produce antagonism at the SR-3 (Ki = 29.5 nM).


References

1. Schlicker, E., et al. 1992. Br. J. Pharmacol. 105: 732-738. PMID: 1628159
2. Swedberg, M.D., et al. 1992. J. Pharmacol. Exp. Ther. 263: 1015-1022. PMID: 1335050
3. Göthert, M., et al. 1995. Br. J. Pharmacol. 114: 269-274. PMID: 7881726
4. de Almeida, R.M., et al. 2002. Neuropsychopharmacology. 27: 171-181. PMID: 12093591
5. Watanabe, A., et al. 2006. Nucl. Med. Biol. 33: 325-332. PMID: 16631081

Physical State :
Solid
Solubility :
Soluble in water (25 mg/ml), and DMSO (100 mM).
Storage :
Store at room temperature
Melting Point :
126-128° C
Boiling Point :
364.1° C at 760 mmHg (Predicted)
Ki Data :
5-HT1B receptor: Ki= 28 nM; 5-HT1A receptor: Ki= 150 nM; 5-HT2 receptor: Ki= 1490 nM; 5-HT3 receptor: Ki= 29.5 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6917943
SMILES :
C1CNCCC1SC2=NC(=CC=C2)Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 173ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 81ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
--%>

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2018 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.