Anpirtoline hydrochloride A SR-1B agonist

Anpirtoline hydrochloride (CAS 98330-05-3)

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Synonym: 2-Chloro-6-piperidin-4-ylsulfanylpyridine hydrochloride
Application: A SR-1B agonist
CAS Number: 98330-05-3
Purity: 99%
Molecular Weight: 265.20
Molecular Formula: C10H13ClN2S HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Anpirtoline hydrochloride is a selective agonist of SR-1B. Anpirtoline shows strong selectivity at SR-1B (Ki = 28 nM) over the SR-1A (Ki = 150 nM) and SR-2 (Ki = 1.49 μM) serotonin receptor subtypes. Anpirtoline is also described to produce antagonism at the SR-3 (Ki = 29.5 nM).


1. Schlicker, E., et al. 1992. Br. J. Pharmacol. 105: 732-738. PMID: 1628159
2. Swedberg, M.D., et al. 1992. J. Pharmacol. Exp. Ther. 263: 1015-1022. PMID: 1335050
3. Göthert, M., et al. 1995. Br. J. Pharmacol. 114: 269-274. PMID: 7881726
4. de Almeida, R.M., et al. 2002. Neuropsychopharmacology. 27: 171-181. PMID: 12093591
5. Watanabe, A., et al. 2006. Nucl. Med. Biol. 33: 325-332. PMID: 16631081

Physical State :
Solubility :
Soluble in water (25 mg/ml), and DMSO (100 mM).
Storage :
Store at room temperature
Melting Point :
126-128° C
Boiling Point :
364.1° C at 760 mmHg (Predicted)
Ki Data :
5-HT1B receptor: Ki= 28 nM; 5-HT1A receptor: Ki= 150 nM; 5-HT2 receptor: Ki= 1490 nM; 5-HT3 receptor: Ki= 29.5 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :

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Certificate of Analysis

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