Anisomycin

Anisomycin (CAS 22862-76-6)

Anisomycin | CAS 22862-76-6 is rated 5.0 out of 5 by 2.
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Synonym: Flagecidin; 2-(p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate
Application: Activator of JNK (c-Jun N-terminal kinases) and p38
CAS Number: 22862-76-6
Purity: ≥98%
Molecular Weight: 265.30
Molecular Formula: C14H19NO4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Anisomycin is a phenylpyrolidine derivative shown to strongly activate the stress-induced MAP kinases JNK and p38. This activity results in the induction of the immediate-early genes: c-Fos, c-Jun, Fos B, Jun B and Jun D, and enhanced phosphorylation of p54/nrb, ATF-2, ERK, Caldesmon, IRS-1 and IRS-2. This compound behaves as a true signaling agonist, and has been implicated to play an important role in hyperosmolarity and UV-stimulated responses. Anisomycin has also been shown to increase the phosphorylation of p70 S6 kinase α.


References

1. Kochi, S.K. and Collier, R.J. 1993. Exp. Cell Res. 208: 296-302. PMID: 8359223
2. Kardalinou, E., et al. 1994. Mol. Cell. Biol. 14: 1066-1074. PMID: 8289787
3. Kyriakis, J.M., et al. 1994. Nature. 369: 156-160. PMID: 8177321
4. Sánchez, I., et al. 1994. Nature. 372: 794-798. PMID: 7997269
5. Hazzalin, C.A., et al. 1998. Mol. Cell. Biol. 18: 1844-1854. PMID: 9528756
6. Okulski, P., et al. 2002. Neuroscience. 114: 1-5. PMID: 12207948
7. Rudy, J.W., et al. 2006. Learn. Mem. 13: 1-3. PMID: 16452648
8. Mawji, I.A., et al. 2007. Cancer Res. 67: 8307-8315. PMID: 17804746
9. Kukushkin, A.N., et al. 2008. J. Cell. Biochem. 103: 1005-1012. PMID: 17647273

Usage :
Used at 300 ng/ml
Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in methanol (20 mg/ml clear, faint yellow solution), ethanol (25 mg/ml), DMSO (50 mg/ml), alcohols, esters, ketones, chloroform, benzene (slightly), toluene (slightly), hexane (slightly), water (2 mg/ml), and ethyl acetate (10 mg/ml clear, colorless solution), DMF (20 mg/ml), and PBS pH 7.2 (0.5 mg/ml).
Storage :
Store at 4° C
Melting Point :
140-141° C
Boiling Point :
398.72° C at 760 mmHg
Density :
~1.21 g/cm3 (Predicted)
Refractive Index :
n20D ~1.56 (Predicted)
Optical Activity :
α23/D -30° in methanol
pK Values :
pKa: 7.9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
BZ9800000
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
253602
Merck Index :
14: 670
MDL Number :
MFCD00077650
EC Number :
245-269-7
Beilstein Registry :
20705
SMILES :
CC(=O)O[C@@H]1[C@H](CN[C@@H]1CC2=CC=C(C=C2)OC)O

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Anisomycin  Product Citations

See how others have used Anisomycin. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 20 total

PMID: # 26903079  Fu, J. et al. 2016. Cytotechnology.

PMID: # 25744026  Jia, J. et al. 2015. Cell Death Differ. 22: 1754-63.

PMID: # 25371719  Guo, L. et al. 2014. Experimental and therapeutic medicine. 8: 1707-1712.

PMID: # 23246481  Wang, F. et al. 2013. Toxicology. 305: 10-9.

PMID: # 22185719  Makhdoumi-Kakhki, A. et al. 2012. Microbes Environ. 27: 87-93.

PMID: # 16215981  Buitrago, CG. et al. 2006. J. Cell. Biochem. 97: 698-708.

PMID: # 15708845  Tanos, T. et al. 2005. J. Biol. Chem. 280: 18842-18852.

PMID: # 15722358  Wu, JJ. et al. 2005. J. Biol. Chem. 280: 16461-16466.

PMID: # 15068801  Marinissen, M. et al. 2004. Molecular Cell. 14: 29-41.

PMID: # 12582162  Li, Y. et al. 2003. J. Biol. Chem. 278: 13663-13671.

Citations 1 to 10 of 20 total
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Rated 5 out of 5 by from Anisomycin was shown to increase the amount of p Anisomycin was shown to increase the amount of p-ATF-2 protein, and reduce the amount of non-phosphorylated ATF-2. Determined by WB. -SCBT QC
Date published: 2015-04-11
Rated 5 out of 5 by from It has been reported that Anisomycin activates It has been reported that Anisomycin activates JNK and P38 proteins because of the cellular stresses caused by the chemical. Tanos used Anisomycin to cause cellular stress along side UV stressed cells to study its effect on c-Fos phosphorylation (PubMed ID 15708845). -SCBT Publication Review
Date published: 2015-04-11
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