Angiogenesis Inhibitor A cell-permeable indolinone

Angiogenesis Inhibitor (CAS 186611-44-9)

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Synonym: (Z,E)-3-(Imidazol-4-ylmethylene)indolin-2-one
Application: A cell-permeable indolinone
CAS Number: 186611-44-9
Purity: ≥95%
Molecular Weight: 211.2
Molecular Formula: C12H9N3O
* Refer to Certificate of Analysis for lot specific data (including water content).

Angiogenesis Inhibitor is a cell-permeable indolinone compound that displays anti-angiogenesis properties with a potency that is comparable to that of SU5416. Angiogenesis Inhibitor also acts as a moderate ATP-competitive inhibitor of EGFR (hEGF-R tyrosine kinase) activity.


References

1. Braud, Emmanuelle., et al., 2003. Potential inhibitors of angiogenesis. Part I: 3-(imidazol-4(5)-ylmethylene)indolin-2-ones. Journal of enzyme inhibition and medicinal chemistry. 18(3): 243-52. PMID: 14506915

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml).
Storage :
Store at 4° C
IC50 :
hEGF-R tyrosine kinase activity: IC50 = 10 µM
pK Values :
pKa: 12.23 (Predicted), pKb: 4.80 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6419833
SMILES :
C1=CC=C2C(=C1)/C(=C\C3=CN=CN3)/C(=O)N2

Download SDS (MSDS)

Certificate of Analysis

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