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AMPK Activator is a furancarboxylic acid derivative that can permeate the cell and partially inhibit the mitochondrial complex I. Research shows that AMPK Activator increases glucose uptake in L6 myocytes, and inhibits CCL2-induced mTORC1 activity and survivin expression in human prostate cancer PC-3 cells (sc-2220). In multiple myeloma cells, AMPK Activator inhibits cell growth.
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2. Baumann, P., et al. 2007. Exp. Cell Res. 313: 3592-3603. PMID: 17669398
3. Roca, H., et al. 2009. Neoplasia. 11: 1309-1317. PMID: 20019839
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