Amphotericin B trihydrate An antifungal and antibiotic

Amphotericin B trihydrate (CAS 1397-89-3)

Amphotericin B trihydrate | CAS 1397-89-3 is rated 5.0 out of 5 by 1.
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Application: An antifungal and antibiotic
CAS Number: 1397-89-3
Molecular Weight: 978.12
Molecular Formula: C47H73NO173H2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Amphotericin B trihydrate is a polyene antifungal antibiotic that forms channels in fungal membranes inducing non-specific loss of low molecular weight molecules to leak out. Its mechanism of action is to bind to sterols and disrupt the osmotic integrity of the fungal membrane. In addition to Amphotericin B trihydrate's antifungal activity it has been used against leishmaniasis caused by protozoan parasites of the Leishmania genus. Amphotericin B trihydrate was observed to cause suppression of bone marrow progenitor cells and to induce Actinomycin D (sc-200906) sensitivity in drug resistant HELA cells in vitro.


References

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2. Presant, C.A., et al. 1984. Cancer Treat Rep. 68: 651-654. PMID: 6201270
3. Barth, C., et al. 1993. Biophys. J. 64: 92-97. PMID: 7679300
4. Charak, B.S., et al. 1994. Br. J. Haematol. 88: 693-698. PMID: 7529537
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Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16213015
SMILES :
CC1C=CC=CC=CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC(C(CCC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O

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Rated 5 out of 5 by from van de Sande van de Sande, WW. et al. (PubMed 26150103) reported that Amphotericin B but not itraconazole is able to prevent grain formation in experimental Madurella mycetomatis mycetoma in mice. -SCBT Publication Review
Date published: 2015-07-01
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