Amorolfine hydrochloride A broad-based antifungal agent which blocks ergosterol biosynthesis

Amorolfine hydrochloride (CAS 78613-38-4)

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Synonym: Loceryl; Amorolfin; Curanail
Application: A broad-based antifungal agent which blocks ergosterol biosynthesis
CAS Number: 78613-38-4
Purity: ≥99%
Molecular Weight: 353.97
Molecular Formula: C21H35ON•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Amorolfine is a broad-based antifungal agent with fungicidal effects against most fungi, dermatophytes and yeasts. Amorolfine blocks ergosterol biosynthesis by interfering with delta 14 reduction and the delta 7-8 isomerisation.


References

1. Hiratani, T. et al. 1991. Jpn J Antibiot. 44(9): 993-1006. PMID: 1960861
2. Jo Siu, W.J. et al. 2013. Antimicrob. Agents Chemother. 57(4): 1610-1616. PMID: 23318803
3. Hau, C.S. et al. 2013. J. Dermatol. Sci. PMID: 23688403

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (≥5 mg/ml,warmed), water (9l mg/ml), and ethanol (71 mg/ml).
Storage :
Desiccate at room temperature
Melting Point :
206-208° C
Refractive Index :
n20D 5.77
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
Transport :
UN 3077, Class 9, Packing group III
PubChem CID :
54259
MDL Number :
MFCD00903738
Beilstein Registry :
9364702
SMILES :
CCC(C)(C)C1=CC=C(C=C1)CC(C)CN2C[C@H](O[C@H](C2)C)C.Cl

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Certificate of Analysis

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