Amikacin (free base) An aminoglycoside antibiotic derived from kanamycin A

Amikacin (free base) (CAS 37517-28-5)

Amikacin (free base) | CAS 37517-28-5 is rated 5.0 out of 5 by 1.
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Synonym: N1-[(S)-4-Amino-2-hydroxybutyryl]kanamycin A
Application: An aminoglycoside antibiotic derived from kanamycin A
CAS Number: 37517-28-5
Molecular Weight: 585.60
Molecular Formula: C22H43N5O13
* Refer to Certificate of Analysis for lot specific data (including water content).
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Amikacin (free base) is an aminoglycoside antibiotic derived from kanamycin A. Effective against Gram-negative and Gram-positive bacteria.


References

Antimicrobial activity of amikacin combinations against Enterobacteriaceae moderately susceptible to third-generation cephalosporins: R.N. Jones, et al.; Antimicrob. Agents Chemother. 22, 985 (1982) BB-K 8, a new semisynthetic aminoglycoside antibiotic: H. Kawaguchi, et al.; J Antibiot (Tokyo) 25, 695 (1972) An overview of amikacin: A. M. Ristuccia & B. A. Cunha; Ther. Drug Monit. 7, 12 (1985) New uses for older antibiotics: nitrofurantoin, amikacin, colistin, polymyxin B, doxycycline, and minocycline revisited: B.A. Cunha; Med. Clin. North Am. 90, 1089 (2006)

Physical State :
Solid
Solubility :
Soluble in water (partly).
Storage :
Store at 4° C
Melting Point :
214-215° C
Boiling Point :
~981.8° C at 760 mmHg (Predicted)
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
pK Values :
pKa: 12.94 (Predicted), pKb: 9.52 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
37768
Merck Index :
14: 405
MDL Number :
MFCD00883675
EC Number :
253-538-5
Beilstein Registry :
5915117
SMILES :
C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1NC(=O)[C@H](CCN)O)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)N)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CN)O)O)O)N

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Certificate of Analysis

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Rated 5 out of 5 by from Lopez Lopez, C. et al. (PubMed 26169414) reported inhibition of AAC(6')-Ib-mediated resistance to the antibiotic Amikacin in Acinetobacter baumannii by an antisense peptide-conjugated 2',4'-bridged nucleic acid-NC-DNA hybrid oligomer. -SCBT Publication Review
Date published: 2015-02-11
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