Amikacin (free base) is an aminoglycoside antibiotic derived from kanamycin A. Effective against Gram-negative and Gram-positive bacteria.
Antimicrobial activity of amikacin combinations against Enterobacteriaceae moderately susceptible to third-generation cephalosporins: R.N. Jones, et al.; Antimicrob. Agents Chemother. 22, 985 (1982) BB-K 8, a new semisynthetic aminoglycoside antibiotic: H. Kawaguchi, et al.; J Antibiot (Tokyo) 25, 695 (1972) An overview of amikacin: A. M. Ristuccia & B. A. Cunha; Ther. Drug Monit. 7, 12 (1985) New uses for older antibiotics: nitrofurantoin, amikacin, colistin, polymyxin B, doxycycline, and minocycline revisited: B.A. Cunha; Med. Clin. North Am. 90, 1089 (2006)
Soluble in water (partly).
Store at 4° C
~981.8° C at 760 mmHg (Predicted)
~1.6 g/cm3 (Predicted)
n20D 1.66 (Predicted)
pKa: 12.94 (Predicted), pKb: 9.52 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
LopezLopez, C. et al. (PubMed 26169414) reported inhibition of AAC(6')-Ib-mediated resistance to the antibiotic Amikacin in Acinetobacter baumannii by an antisense peptide-conjugated 2',4'-bridged nucleic acid-NC-DNA hybrid oligomer. -SCBT Publication Review
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