Amikacin disulfateAn aminoglycoside antibiotic that is active against gram-negative bacteria

Amikacin disulfate (CAS 39831-55-5)

Amikacin disulfate | CAS 39831-55-5 is rated 5.0 out of 5 by 1.
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Application: An aminoglycoside antibiotic that is active against gram-negative bacteria
CAS Number: 39831-55-5
Molecular Weight: 781.75
Molecular Formula: C22H43N5O132H2SO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Amikacin disulfate, also known as BB-K 8, is an aminoglycoside antibiotic that is active against gram-negative bacteria. The activity of Amikacin is similar to that of Kanamycin (sc-29069) and Gentamicin (sc-29066). Amikacin has been used in different types of renal studies. We supply the Amikacin disulfate form.


References

1. Kawaguchi, H., et al. 1972. J. Antibiot. 25: 695-708. PMID: 4568692
2. Cabana, B.E., et al. 1973. Antimicrob. Agents Chemother. 3: 478-483. PMID: 4790604
3. Yu, P.K., et al. 1973. Antimicrob. Agents Chemother. 4: 133-139. PMID: 4208506
4. Sharp, P.M., et al. 1974. Antimicrob. Agents Chemother. 5: 435-438. PMID: 4462458
5. Bodey, G.P., et al. 1974. Antimicrob. Agents Chemother. 5: 508-512. PMID: 4462465
6. Lanao, J.M., et al. 1979. Int J Clin Pharmacol Biopharm. 17: 171-175. PMID: 447438

Physical State :
Solid
Derived From :
Semisynthetic from kanamycin A
Solubility :
Soluble in water (50 mg/ml), DMSO (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C). Insoluble in acetone.
Storage :
Store at -20° C
Melting Point :
220-230° C (lit.)(dec.)
Optical Activity :
α22/D +74.75°, c = 1 in water; α23/D +99°, c = 1 in water
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
WK1961200
PubChem CID :
38351
Merck Index :
14: 405
MDL Number :
MFCD00167475
EC Number :
254-648-6
Beilstein Registry :
6172633
SMILES :
C1C(C(C(C(C1NC(=O)C(CCN)O)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(C(C(C(O3)CN)O)O)O)N.OS(=O)(=O)O.OS(=O)(=O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Sharp et al Sharp et al. (PubMed ID 4462458) used the antibiotic, amikacin disulfide, to treat patients with antibiotic resistant urinary tract infections. -SCBT Publication Review
Date published: 2015-07-16
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