Amifostine is a broad-spectrum radio- and chemoprotector. It restores transcriptional activity of specific p53 mutants, prevents chemotherapy-induced apoptosis and upregulates HIF-1α. Amifostine offers a selective protection to normal cells over tumor cells due to normal cells having a 275-fold greater concentration of alkaline phosphatase, by reducing renal toxicity, higher pH and better vascularity of the normal tissue. In physiological conditions, Amifostine is rapidly dephosporylated by alkaline phosphatase into an active free thiol. As a free thiol, Amifostine can act as a scavenger of free radicals against cytotoxic drugs. The compound has also displayed cytoprotectivity against alkylating drugs and cisplatin (sc-200896). Amifostine is an activator of p53.
1. Santini, V. and Giles, F.J. 1999. Haematologica. 84: 1035-1042. PMID: 10553165 2. Provinciali, M., et al. 1999. Life Sci. 64: 1525-1532. PMID: 10353617 3. Capizzi, R.L. and Oster, W. 2000. Int. J. Hematol. 72: 425-435. PMID: 11197208 4. Maurici, D., et al. 2001. Oncogene. 20: 3533-3540. PMID: 11429700 5. Koukourakis, M.I., et al. 2004. Cancer Chemother. Pharmacol. 53: 8-14. PMID: 14574457
Soluble in water (1000 mg/ml).
Store at room temperature
86.28° C (Predicted)
~441.70° C at 760 mmHg (Predicted)
~1.4 g/cm3 (Predicted)
n20D 1.56 (Predicted)
pKa: 1.28, pKb: 10.16
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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See how others have used Amifostine. Click on the entry to view the PubMed entry
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Rated 5 out of
VujaskovicVujaskovic, et. al. (PubMed ID 17869666) tested the effects of amifostine on acute and chronic esophageal injury in rodents. They found that if amifostine is administered before each radiation round, it protects against acute and chronic injury. -SCBT Publication Review
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