Amidepsine D An inhibitor of diacylglycerol acyltransferase (DGAT)

Amidepsine D

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Application: An inhibitor of diacylglycerol acyltransferase (DGAT)
Molecular Weight: 496.5
Molecular Formula: C26H24O10
* Refer to Certificate of Analysis for lot specific data (including water content).
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Amidepsine D is an inhibitor of diacylglycerol acyltransferase (DGAT). Amidepsine D shows inhibitory effects in rat liver microsomes (IC50=17.5μM) and Raji cells (IC50=2.8μM). Excessive accumulation of triacetylglycerol is produced by DGAT which may cause fatty liver, obesity and hypertriglyceridemia, and may lead to atherosclerosis, diabetes and metabolic disorders.


References

H. Tomoda, et al.; J. Antibiot. 48, 937 (1995). Tomoda, et al.; J. Antibiot. 48, 942 (1995).

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in methanol (1mg/ml); insoluble in water.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10391109
SMILES :
CC1=CC(=CC(=C1C(=O)O)O)OC(=O)C2=C(C=C(C=C2C)OC(=O)C3=C(C=C(C=C3C)OC)OC)O

Download SDS (MSDS)

Certificate of Analysis

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