Amastatin hydrochloride A competitive inhibitor of several aminopeptidases

Amastatin hydrochloride (CAS 100938-10-1)

Amastatin hydrochloride | CAS 100938-10-1 is rated 5.0 out of 5 by 1.
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Synonym: Amastatin HCl
Application: A competitive inhibitor of several aminopeptidases
CAS Number: 100938-10-1
Purity: ≥97%
Molecular Weight: 511.01
Molecular Formula: C21H38N4O8•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Amastatin hydrochloride is a slow, tightly binding, competitive inhibitor of human serum aminopeptidase A, human serum aminopeptidase M (CD13), pig kidney leucine aminopeptidase (LAP3), and tyrosine aminopeptidase, but not of aminopeptidase B. The compound has been used to potentiate the action of some bioactive peptides by inhibiting their degradation by aminopeptidases. Amastatin hydrochloride has been shown to slightly decrease the conversion of angiontensin II to angiotensin III, but significantly increases the potency of angiotensin III and des(Asp1)angiotensin I. In addition, the Suc-Ala-Ala-Pro-Leu-pNA amidolytic enzyme activities were completely inhibited with the addition of amastatin hydrochloride.


References

1. Aoyagi, T., et al. 1978. J. Antibiot. 31: 636-638. PMID: 681249
2. Rich, D.H., et al. 1984. J. Med. Chem. 27: 417-422. PMID: 6142952
3. Ahmad, S., et al. 1990. J. Pharmacol. Exp. Ther. 252: 643-650. PMID: 1968973
4. Matsuda, Y., et al. 2000. Arch. Androl. 44: 1-9. PMID: 10690759

Physical State :
Solid
Derived From :
Synthetic
Solubility :
Soluble in acetic acid, water, and ethanol.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
180936
MDL Number :
MFCD00058071
Beilstein Registry :
8888370
SMILES :
CC(C)C[C@H]([C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)O)O)N.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Kang Kang, et al. (PubMed ID 25595410) report that amastatin exhibited an inhibitory effect on PvMetAP1 (Plasmodium vivax). -SCBT Publication Review
Date published: 2015-04-18
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