Amastatin hydrochloride is a slow, tightly binding, competitive inhibitor of human serum aminopeptidase A, human serum aminopeptidase M (CD13), pig kidney leucine aminopeptidase (LAP3), and tyrosine aminopeptidase, but not of aminopeptidase B. The compound has been used to potentiate the action of some bioactive peptides by inhibiting their degradation by aminopeptidases. Amastatin hydrochloride has been shown to slightly decrease the conversion of angiontensin II to angiotensin III, but significantly increases the potency of angiotensin III and des(Asp1)angiotensin I. In addition, the Suc-Ala-Ala-Pro-Leu-pNA amidolytic enzyme activities were completely inhibited with the addition of amastatin hydrochloride.
1. Aoyagi, T., et al. 1978. J. Antibiot. 31: 636-638. PMID: 681249
2. Rich, D.H., et al. 1984. J. Med. Chem. 27: 417-422. PMID: 6142952
3. Ahmad, S., et al. 1990. J. Pharmacol. Exp. Ther. 252: 643-650. PMID: 1968973
4. Matsuda, Y., et al. 2000. Arch. Androl. 44: 1-9. PMID: 10690759
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.