AM 80 is a RARα (retinoic acid receptor α) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. AM 80 displays anticancer activity against acute promyelocytic leukemia in vitro and exhibits antiproliferative effects against a variety of tumor cell lines. AM 80 is an activator of RAR β.
1. Kagechika, H., et al. 1988. J. Med. Chem. 31: 2182-2192. PMID: 3184125 2. Jimi, K., et al. 2007. Int. J. Oncol. 31: 397-404. PMID: 17611697 3. Takenaga, Y., et al. 2009. Biol. Pharm. Bull. 32: 225-231. PMID: 1918238 Jin, Y. et al. 2014. Int. Immunopharmacol. 23(2): 537-545. PMID: 25448496
Soluble in 1.1eq. NaOH (100 mM), DMSO (50 mM), methanol, and water (slightly).
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