AM 1172A potent and selective inhibitor of anandamide uptake and FAAH

AM 1172 (CAS 251908-92-6)

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Synonym: AM679; AM2201-d5; AM2201
Application: A potent and selective inhibitor of anandamide uptake and FAAH
CAS Number: 251908-92-6
Molecular Weight: 409.6
Molecular Formula: C27H39NO2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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AM 1172 is a potent and selective inhibitor of anandamide uptake, resistant to FAAH (fatty acid amide hydrolase) hydrolysis. Metabolically stable "reversed" isomer of AM 404 (sc-200363). AM 1172 is an inhibitor of FAAH. AM 1172 is an activator of CB1 and CB2.


References

Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172: D. Fegley, et al.; PNAS 101, 8756 (2004)

Usage :
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Formulation :
Solution in ethanol
Physical State :
Liquid
Solubility :
Soluble in water (0.15 mg/ml at 20° C), ethanol, DMSO (~30 mg/ml), DMF (~30 mg/ml), and PBS pH 7.2 (~0.15 mg/ml).
Storage :
Store at -20° C
Boiling Point :
78° C
Refractive Index :
n20D 1.54 (Predicted)
IC50 :
CB2: EC5050 = 189 nM; Uptake of tritiated AEA: EC5050 = 1.5 µM; Anandamide uptake: IC50 = 2.1-2.5 µM; N-arachidonylethanolamine accumulation: IC50 = 24 µM; N-palmitoylethanolamine hydrolysis: IC50 = 36 µM
Ki Data :
N-arachidonylethanolamine hydrolysis: Ki= 3 µM; FAAH: Ki= 3.18 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
CV4830000
PubChem CID :
10364179
MDL Number :
MFCD08062148
SMILES :
CCCCC/C=C\\C/C=C\\C/C=C\\C/C=C\\CCCCNC(=O)C1=CC=C(C=C1)O

Download SDS (MSDS)

Certificate of Analysis

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