alpha-Melanocyte stimulating hormone An endogenous melanocortin receptor agonist

α-Melanocyte stimulating hormone (CAS 581-05-5)

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Synonym: α-MSH; α-Melanotropin
Application: An endogenous melanocortin receptor agonist
CAS Number: 581-05-5
Molecular Weight: 1664.88
Molecular Formula: C77H109N21O19S
* Refer to Certificate of Analysis for lot specific data (including water content).
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α-Melanocyte stimulating hormone is an endogenous melanocortin receptor (MC-R) agonist (Ki values are 0.12, 31, 660 and 5700 nM for MC1-R, MC3-R, MC4-R and MC5-R receptors respectively). This peptide also shows anti-inflammatory properties and can antagonize many proinflammatory mediators, such as TNF-α, IL-^, and NO while also inducing cytokine IL-10 (anti-inflammatory). α-Melanocyte stimulating hormone is an inhibitor of NOS2.

Appearance :
Powder
Physical State :
Solid
Sequence :
SYSMEHFRWGKPV
Solubility :
Soluble in water (~1 mg/ml).
Storage :
Store at -20° C
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
Melanocortin receptor: EC5050 = 0.02 nM; MC1-R: IC50 = 0.4 nM (human); MC4-R: IC50 = 5 nM (human); MC5-R: IC50 = 18 nM (human); MC3-R: IC50 = 19 nM (human)
Ki Data :
MC1-R: Ki= 0.12 nM (human); MC4-R: Ki= 8.6 nM (human); MC3-R: Ki= 31 nM (human); MC5-R: Ki= 150 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
YV9350602
PubChem CID :
44273719
Merck Index :
14: 6295
MDL Number :
MFCD00133062
Beilstein Registry :
741840
SMILES :
CC(C)C(C(=O)N)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)CNC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC5=CN=CN5)NC(=O)C(CCC(=O)O)NC(=O)C(CCSC)NC(=O)C(CO)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C(CO)NC(=O)C

Download SDS (MSDS)

Certificate of Analysis

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