alpha,beta-Methyleneadenosine 5prime-triphosphate trisodium saltA P2-purinoceptor agonist

alpha,beta-Methyleneadenosine 5′-triphosphate trisodium salt (CAS 7292-42-4)

alpha,beta-Methyleneadenosine 5′-triphosphate trisodium salt | CAS 7292-42-4 is rated 5.0 out of 5 by 1.
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Synonym: [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[hydroxy(phosphonooxy)phosphoryl]methyl]phosphinic acid
Application: A P2-purinoceptor agonist
CAS Number: 7292-42-4
Purity: >98%
Molecular Weight: 571.15
Molecular Formula: C11H15N5Na3O12P3
* Refer to Certificate of Analysis for lot specific data (including water content).
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α,β-Methyleneadenosine 5'-triphosphate trisodium salt is a P2-purinoceptor agonist. It has also been shown to inhibit adenylate cyclase (Ki = 0.5 µM).


References

Krug et al (1973) a,b-Methylene-adenosine 5'-triphosphate. J.Biol.Chem. 248 1203. Burnstock and Kennedy (1985) Is there a basis for distinguishing two types of P2-purinoceptor? Gen.Pharmacol. 16 433.

Physical State :
Solid
Solubility :
Soluble in water (100 mM).
Storage :
Store at -20° C
Ki Data :
adenylate cyclase: Ki= 0.5 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
AU7373000
PubChem CID :
56972213
MDL Number :
MFCD11519965
EC Number :
230-723-9
SMILES :
C1=NC2=C(C(=N1)N)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(CP(=O)(O)OP(=O)(O)O)O)O)O.[Na].[Na].[Na]

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Hung Hung, et al. (PubMed ID 25433238) found that micro-injections of , -methylene adenosine 5'-triphosphate into the DFA (dorsal facial area of the medulla of cats) resulted in an increase in common carotid artery (CCA) flow. -SCBT Publication Review
Date published: 2015-07-04
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