ALLN A peptide aldehyde inhibitor of calpains and cathepsins

ALLN (CAS 110044-82-1)

ALLN | CAS 110044-82-1 is rated 5.0 out of 5 by 1.
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| See product citations (6)
Synonym: N-acetyl-Leu-Leu-Norleu-al; Calpain Inhibitor I
Application: A peptide aldehyde inhibitor of calpains and cathepsins
CAS Number: 110044-82-1
Purity: ≥95%
Molecular Weight: 383.53
Molecular Formula: C20H37N3O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
ALLN sc-221236 5 mg $85.00

ALLN is an inhibitor of Calpain 1 (calpain I, Ki = 190 nM), Calpain 2 (calpain II , Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). It inhibits neutral cysteine proteases and proteasome (Ki = 6 μM). It inhibits apoptosis in thymocytes and metamyelocytes. It also inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. ALLN inhibits the proteolysis of IκBα and IκBβ by the ubiquitin-proteasome complex. Furthermore, it protects against neuronal damage caused by hypoxia and ischemia. ALLN also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml), ethanol (5 mg/ml), methanol, and DMSO. Insoluble in water, and aqueous buffers.
Storage :
Store at -20° C
Melting Point :
267.52° C (Predicted)
Boiling Point :
632.19° C at 760 mmHg (Predicted)
Density :
1.02 g/cm3 (Predicted)
Refractive Index :
n20D 1.47 (Predicted)
Ki Data :
calpain I : Ki= 190 nM; calpain II: Ki= 220 nM; cathepsin L: Ki= 500 pM; cathepsin B: Ki= 150 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
443118
MDL Number :
MFCD00065505
Beilstein Registry :
7656053
SMILES :
CCCC[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)C

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Certificate of Analysis

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ALLNProduct Citations

See how others have used ALLN. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 25928566
Aslanidis, A. et al. 2015. Activated microglia/macrophage whey acidic protein (AMWAP) inhibits NFκB signaling and induces a neuroprotective phenotype in microglia. J Neuroinflammation. 12: -.

PMID: # 25356863
Yoon, S. et al. 2014. Caspase-dependent cell death-associated release of nucleosome and damage-associated molecular patterns. Cell Death Dis. 5: e1494.

PMID: # 24068677
Green, SE. et al. 2013. Uptake, p53 pathway activation, and cytotoxic responses for Co(II) and Ni(II) in human lung cells: implications for carcinogenicity. Toxicological sciences : an official journal of the Society of Toxicology. 136: 467-77.

PMID: # 22684109
Zhao, X. et al. 2012. Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. J. Clin. Invest.. 122: 2417-27.

PMID: # 16690988
Chambellan, A. et al. 2006. Gene expression profile of human airway epithelium induced by hyperoxia in vivo. Am. J. Respir. Cell Mol. Biol.. 35: 424-35.

PMID: # 15930385
Park, SY. et al. 2005. The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which tau mediates beta-amyloid-induced neurodegeneration J Neurosci. 25(22): 5365-5375.

Citations 1 to 6 of 6 total
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Rated 5 out of 5 by from Worked well in my experiments Worked well in my experiments, happy with purchase.
Date published: 2015-06-29
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