ALLN A peptide aldehyde inhibitor of calpains and cathepsins

ALLN (CAS 110044-82-1)

ALLN | CAS 110044-82-1 is rated 5.0 out of 5 by 1.
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| See product citations (6)
Synonym: N-acetyl-Leu-Leu-Norleu-al; Calpain Inhibitor I
Application: A peptide aldehyde inhibitor of calpains and cathepsins
CAS Number: 110044-82-1
Purity: ≥95%
Molecular Weight: 383.53
Molecular Formula: C20H37N3O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
ALLN sc-221236 5 mg $85.00

ALLN is an inhibitor of Calpain 1 (calpain I, Ki = 190 nM), Calpain 2 (calpain II , Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). It inhibits neutral cysteine proteases and proteasome (Ki = 6 μM). It inhibits apoptosis in thymocytes and metamyelocytes. It also inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. ALLN inhibits the proteolysis of IκBα and IκBβ by the ubiquitin-proteasome complex. Furthermore, it protects against neuronal damage caused by hypoxia and ischemia. ALLN also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml), ethanol (5 mg/ml), methanol, and DMSO. Insoluble in water, and aqueous buffers.
Storage :
Store at -20° C
Melting Point :
267.52° C (Predicted)
Boiling Point :
632.19° C at 760 mmHg (Predicted)
Density :
1.02 g/cm3 (Predicted)
Refractive Index :
n20D 1.47 (Predicted)
Ki Data :
calpain I : Ki= 190 nM; calpain II: Ki= 220 nM; cathepsin L: Ki= 500 pM; cathepsin B: Ki= 150 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
443118
MDL Number :
MFCD00065505
Beilstein Registry :
7656053
SMILES :
CCCC[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)C

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Certificate of Analysis

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ALLNProduct Citations

See how others have used ALLN. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 25928566  Aslanidis, A. et al. 2015. J Neuroinflammation. 12: -.

PMID: # 25356863  Yoon, S. et al. 2014. Cell Death Dis. 5: e1494.

PMID: # 24068677  Green, SE. et al. 2013. Toxicological sciences : an official journal of the Society of Toxicology. 136: 467-77.

PMID: # 22684109  Zhao, X. et al. 2012. J. Clin. Invest. 122: 2417-27.

PMID: # 16690988  Chambellan, A. et al. 2006. Am. J. Respir. Cell Mol. Biol. 35: 424-35.

PMID: # 15930385  Park, SY. et al. 2005. J Neurosci. 25(22): 5365-5375.

Citations 1 to 6 of 6 total
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Rated 5 out of 5 by from Worked well in my experiments Worked well in my experiments, happy with purchase.
Date published: 2015-06-29
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