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ALLN is an inhibitor of Calpain 1 (calpain I, Ki = 190 nM), Calpain 2 (calpain II , Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). It inhibits neutral cysteine proteases and proteasome (Ki = 6 μM). It inhibits apoptosis in thymocytes and metamyelocytes. It also inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. ALLN inhibits the proteolysis of IκBα and IκBβ by the ubiquitin-proteasome complex. Furthermore, it protects against neuronal damage caused by hypoxia and ischemia. ALLN also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.
See how others have used ALLN. Click on the entry to view the PubMed entry .
PMID: # 25928566
Aslanidis, A. et al. 2015. Activated microglia/macrophage whey acidic protein (AMWAP) inhibits NFκB signaling and induces a neuroprotective phenotype in microglia. J Neuroinflammation. 12: -.
PMID: # 25356863
Yoon, S. et al. 2014. Caspase-dependent cell death-associated release of nucleosome and damage-associated molecular patterns. Cell Death Dis. 5: e1494.
PMID: # 24068677
Green, SE. et al. 2013. Uptake, p53 pathway activation, and cytotoxic responses for Co(II) and Ni(II) in human lung cells: implications for carcinogenicity. Toxicological sciences : an official journal of the Society of Toxicology. 136: 467-77.
PMID: # 22684109
Zhao, X. et al. 2012. Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. J. Clin. Invest.. 122: 2417-27.
PMID: # 16690988
Chambellan, A. et al. 2006. Gene expression profile of human airway epithelium induced by hyperoxia in vivo. Am. J. Respir. Cell Mol. Biol.. 35: 424-35.
PMID: # 15930385
Park, SY. et al. 2005. The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which tau mediates beta-amyloid-induced neurodegeneration J Neurosci. 25(22): 5365-5375.
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