ALLM (Calpain Inhibitor) A cell-permeable, peptide aldehyde inhibitor of calpains and cathepsins

ALLM (Calpain Inhibitor) (CAS 136632-32-1)

ALLM (Calpain Inhibitor) | CAS 136632-32-1 is rated 5.0 out of 5 by 1.
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Synonym: N-Acetyl-L-leucyl-L-leucyl-L-methioninal; Calpain inhibitor II
Application: A cell-permeable, peptide aldehyde inhibitor of calpains and cathepsins
CAS Number: 136632-32-1
Purity: ≥95%
Molecular Weight: 401.56
Molecular Formula: C19H35N3O4S
* Refer to Certificate of Analysis for lot specific data (including water content).
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ALLM (Calpain Inhibitor) is a cell-permeable, peptide aldehyde inhibitor of calpain I (Ki = 120 nM) and calpain II (Ki = 230 nM). ALLM acts as a very potent inhibitor of cathepsin L (Ki = 0.6 nM) and the strongest inhibitor of cathepsin B (Ki = 100 nM) amongst the peptide aldehydes. This compound inhibits the processing of malaria aspartic hemoglobinases plasmepsins I and II in vitro. ALLM also inhibits other neutral cysteine proteases, and activation-induced programmed cell death. It restores defective immune responses in HIV+ donors. ALLM blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. ALLM also acts as a weak inhibitor of proteasome.


References

1. Sasaki, T., et al. 1990. J. Enzym. Inhib. 3: 195-201. PMID: 2079636
2. Shenoy, A.M. and Brahmi, Z. 1991. Cell. Immunol. 138: 24-34. PMID: 1913839
3. Pintér, M., et al. 1992. Biochemistry. 31: 8201-8206. PMID: 1525160
4. Koohmaraie, M. 1992. Biochimie. 74: 239-245. PMID: 1610937
5. Banik, N.L., et al. 1992. Neurochem. Res. 17: 797-802. PMID: 1641062

Appearance :
Crystalline
Physical State :
Solid
Sequence :
N-Acetyl-Leu-Leu-Met-CHO
Solubility :
Soluble in DMSO (25 mg/ml), ethanol (25 mg/ml), and methanol. Insoluble in Warter.
Storage :
Store at -20° C
Boiling Point :
621.5-731.5° C at 760 mmHg (Predicted)
Density :
1.1 g/cm3
Refractive Index :
n20D 1.495
Ki Data :
cathepsin L: Ki= 0.6 nM; cathepsin B: Ki= 100 nM; calpain I: Ki= 120 nM; calpain II: Ki= 230 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
121855
MDL Number :
MFCD00065506
Beilstein Registry :
7693643
SMILES :
CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C=O)NC(=O)C

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Certificate of Analysis

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ALLM (Calpain Inhibitor)  Product Citations

See how others have used ALLM (Calpain Inhibitor). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 14 total

PMID: # 27766426  Xie, J. et al. 2017. Arch. Virol. 162: 391-400.

PMID: # 27245989  Wang, Q. et al. 2016. Autophagy. 1-15.

PMID: # 25736794  Zhao, PY. et al. 2015. Investigative ophthalmology & visual science. 56: 1916-23.

PMID: # 26581976  Corry, J. et al. 2015. J. Virol. 90: 1311-20.

PMID: # 24412755  Bellei, B. et al. 2014. Cellular signalling. 26: 716-23.

PMID: # 20485379  Kindle, KB. et al. 2010. Leukemia. 24: 1359-1361.

PMID: # 20056606  Li, F. et al. 2010. J. Biol. Chem. 285: 8076-8083.

PMID: # 19109420  Crowley, JL. et al. 2009. Mol. Biol. Cell. 20: 948-962.

PMID: # 19822744  Campbell, M. et al. 2009. Proc. Natl. Acad. Sci. U.S.A. 106: 17817-17822.

PMID: # 17971859  Sheu, ML. et al. 2007. PLoS ONE. 2: e1096.

Citations 1 to 10 of 14 total
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Rated 5 out of 5 by from Li et al Li et al. (PubMed ID 20056606) found that calpain inhibitor, ALLM, prevented the activation of aspartic proteases and significantly reduced Plasmodium oocyte number and infectivity. -SCBT Publication Review
Date published: 2015-01-09
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