Akt Inhibitor IIIAn Akt activation inhibtor with little effect on phosphorylation of downstream kinases

Akt Inhibitor III

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Synonym: SH-6
Application: An Akt activation inhibtor with little effect on phosphorylation of downstream kinases
Molecular Weight: 568.7
Molecular Formula: C28H57O9P
* Refer to Certificate of Analysis for lot specific data (including water content).
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Akt Inhibitor III is a phosphatidylinositol analog that inhibits the activation of Akt and select downstream substrates without decreasing phosphorylation of PDK-1 or other kinases downstream of Ras, such as MAPK. Akt Inhibitor III also acts as a potent inducer of apoptosis and selectively kills a variety of cancer cell lines that contain high levels of active Akt. When used at a concentration of 10 µM, the compound is reported to activate p38α/SAPK2α MAP kinase. At 10 µM Akt Inhibitor III will also inhibit PKA activity.


References

1. Kozikowski, A.P., et al. 2003. J. Am. Chem. Soc. 125: 1144-1145. PMID: 12553797

Physical State :
Solid
Solubility :
Soluble in DMSO
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760283
SMILES :
CCCCCCCCCCCCCCCCCCOC[C@H](COP(=O)(O)OC1CCC(C(C1O)O)O)OC

Download SDS (MSDS)

Certificate of Analysis

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