AG 957, Adamantyl Ester An ~3-4 fold more potent derivative of AG 957

AG 957, Adamantyl Ester

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Application: An ~3-4 fold more potent derivative of AG 957
Molecular Weight: 393.5
Molecular Formula: C24H27NO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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AG 957, Adamantyl Ester is a lipophilic, adamantyl ester form of tyrphostin AG 957 that displays anti-proliferative properties. The product has been shown to be selective and is ~3-4 fold more potent than the bcr/abl kinase inhibitor AG 957. AG 957, Adamantyl Ester Downregulates p210bcr/abl autokinase activity (IC50 = 14 µM). Selectively blocks granulocyte colony formation in CML (chronic myelogenous leukemia) progenitors and inhibits proliferation of K562 cells (IC50 = 9.8 µM) by inducing apoptosis. AG 957, Adamantyl Ester is reported to retain activity in STI571-resistant and p53-null human leukemia cell lines (IC50 ~0.1-0.25 µM).


References

Avramis, I.A., et al. 2002. Cancer Chemother. Pharmacol. 50, 479. Mow, B.M., et al. 2002. Blood 99, 664. Svingen, P.A., et al. 2000. Clin. Cancer Res. 6, 237.

Physical State :
Solid
Solubility :
DMSO or EtOH
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
387042
SMILES :
C1C2CC3CC1CC(C2)(C3)OC(=O)C4=CC=C(C=C4)NCC5=C(C=CC(=C5)O)O

Download SDS (MSDS)

Certificate of Analysis

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