AG 490, m-CF3 An apoptotic and antiproliferative compound

AG 490, m-CF3 (CAS 581797-29-7)

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Synonym: NSC D722757, α-Cyano-(3,4-dihydroxy)-N-(m-trifluoromethyl)benzylcinnamide, 5H4
Application: An apoptotic and antiproliferative compound
CAS Number: 581797-29-7
Molecular Weight: 362.3
Molecular Formula: C18H13F3N2O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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AG 490, m-CF3 is a cell-permeable, m-trifluoromethyl derivative of AG 490 that displays apoptotic and antiproliferative properties. AG 490, m-CF3 inhibits IL-7-induced JAK3 tyrosine phosphorylation in 2E8 cells in vitro and significantly decreases lymph node cellularity in a murine model for B and T cell lymphoma.


References

1. Gu, Ling., et al., 2005. Combinatorial approach to identification of tyrphostin inhibitors of cytokine signaling. Bioorganic & medicinal chemistry. 13(13): 4269-78. PMID: 15869881

Physical State :
Solid
Solubility :
Soluble in DMSO (0.5 mg/ml), and methanol.
Storage :
Store at -20° C
Melting Point :
233.60° C (Predicted)
Boiling Point :
~593.7° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
2E8: IC50 = 1.7 µM; Baf/3 : IC50 = 2.8 µM; Jurkat cells: IC50 = 6.1 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11516050
SMILES :
C1=CC(=CC(=C1)C(F)(F)F)CNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N

Download SDS (MSDS)

Certificate of Analysis

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