AG 490, m-CF3 is a cell-permeable, m-trifluoromethyl derivative of AG 490 that displays apoptotic and antiproliferative properties. AG 490, m-CF3 inhibits IL-7-induced JAK3 tyrosine phosphorylation in 2E8 cells in vitro and significantly decreases lymph node cellularity in a murine model for B and T cell lymphoma.
1. Gu, Ling., et al., 2005. Combinatorial approach to identification of tyrphostin inhibitors of cytokine signaling. Bioorganic & medicinal chemistry. 13(13): 4269-78. PMID: 15869881
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