AEBSF hydrochlorideA TGF beta inhibitor, JNK activator, and p38 Map activator

AEBSF hydrochloride (CAS 30827-99-7)

AEBSF hydrochloride | CAS 30827-99-7 is rated 5.0 out of 5 by 1.
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Synonym: 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride
Application: A TGF beta inhibitor, JNK activator, and p38 Map activator
CAS Number: 30827-99-7
Purity: ≥97%
Molecular Weight: 239.69
Molecular Formula: C8H10FNO2S•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

AEBSF is a broad spectrum, water soluble, irreversible serine protease inhibitor. It has been shown to inhibit the constitutive production of beta amyloid (A beta) in five different human cell lines, both neural and non-neural. AEBSF also inhibits activation of TGFβ (transforming growth factor beta), moderately inhibits CD26 (Dipeptidyl peptidase IV: DPP IV) and activates JNK and p38 MAP kinases. AEBSF is a b-secretase inhibitor that has been shown to inhibit beta amyloid peptide production and enhance APP (amyloid precursor protein) secretion in several cell lines at millimolar concentrations. This product maintains stability at slightly acidic aqueous solutions and serves as a nontoxic alternative to PMSF (sc-3597) and DFP.


References

1. Baker, B.R., et al. 1971. J. Med. Chem. 14: 119-125. PMID: 5544395
2. Markwardt, F., et al. 1974. Biochem. Pharmacol. 23: 2247-2256. PMID: 4859519
3. Lawson, W.B., et al. 1982. Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. 109: 52-60. PMID: 6177608
4. Ohkubo, I., et al. 1994. J. Biochem. 116: 1182-1186. PMID: 7896751
5. Citron, M., et al. 1996. Neuron. 17: 171-179. PMID: 8755488
6. Solovyan, V.T. and Keski-Oja, J. 2006. J. Cell. Physiol. 207: 445-453. PMID: 16447253
7. Seto, T., et al. 2009. Biochem. Biophys. Res. Commun. 379: 681-685. PMID: 19103172

Usage :
• Use AEBSF at the same molar concentrations (0.1 - 1.0 mM) as PMSF for most applications.
Physical State :
Solid
Solubility :
Soluble in water (10 g/L) at 20° C, and DMSO (50 mg/ml).
Storage :
Store at 4° C
Melting Point :
182-184° C (dec.)
pK Values :
pKb: 9.19 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
186136
MDL Number :
MFCD00132962
Beilstein Registry :
7604627
SMILES :
C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl

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Certificate of Analysis

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AEBSF hydrochloride  Product Citations

See how others have used AEBSF hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 11 total

PMID: # 27424747  2016. Methods in molecular biology (Clifton, N.J.). 1450: 85-94.

PMID: # 26154290  Mikuni, S. et al. 2015. PLoS ONE. 10: e0130933.

PMID: # 26646935  Tulic, MK. et al. 2015. Gut.

PMID: # 25774181  Yin, W. et al. 2012. Neural Regen Res. 7: 405-12.

PMID: # 19921247  Zhang, Y. et al. 2010. Planta. 231: 337-348.

PMID: # 14985176  Reilly, D. et al. 2004. Platelets. 15: 43-54.

PMID: # 15221417  Nagasaka, T. et al. 2004. Histochem. Cell Biol. 121: 483-491.

PMID: # 15240346  Nicoletta, JA. et al. 2004. Am. J. Physiol., Cell Physiol. 287: C1366-C1374.

PMID: # 12711590  Wang, XY. et al. 2003. Am. J. Physiol. Gastrointest. Liver Physiol. 285: G593-G601.

PMID: # 12456722  Hou, MC. et al. 2003. J. Cell. Sci. 116: 125-135.

Citations 1 to 10 of 11 total

Is it possible to store AEBSF in solution over a longer time period?

Asked by: AnjaT
Thank you for your question. AEBSF hydrochloride (CAS 30827-99-7) is best stored in solid form at +4 °C. We do not recommend storing this compound in solution, as this can negatively impact the stability and viability of AEBSF. Please get in touch with our technical service if you have further questions.
Answered by: Tech Support Europe
Date published: 2019-06-05

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-3508, is provided as a light yellow powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-17
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Rated 5 out of 5 by from Woodhouse et al Woodhouse et al. (PubMed ID 14500904) used AEBSF hydrochloride to prepare larval brain extracts for western blotting and immunostaining. -SCBT Publication Review
Date published: 2015-07-13
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