Adenylyl Cyclase Type V Inhibitor, NKY80

Adenylyl Cyclase Type V Inhibitor, NKY80 (CAS 299442-43-6)

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Synonym: 2-Amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone
Application: An A cyclase III and V inhibitor
CAS Number: 299442-43-6
Purity: ≥97%
Molecular Weight: 229.2
Molecular Formula: C12H11N3O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Adenylyl Cyclase Type V Inhibitor, NKY80 is a cell-permeable quinazolinone containing a non-nucleoside compound that acts as a potent, selective inhibitor of A cyclase V (adenylyl cyclase (AC) type V isoform) (IC50 = 8.3 μM, 132 μM and 1.7 mM for type V, III and II, respectively) in the presence of Gsα GTPγS-Forskolin. The compound displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition observed is non-competitive with respect to ATP and Forskolin. Adenylyl Cyclase Type V Inhibitor, NKY80 regulates the AC catalytic activity in heart and lung tissues.

Physical State :
Solid
Solubility :
Soluble in DMSO (200 mg/ml), and methanol (5 mg/ml).
Storage :
Store at -20° C
Melting Point :
159.41° C (Predicted)
Boiling Point :
464.87° C at 760 mmHg (Predicted)
Density :
1.36 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
adenylyl cyclase type V: IC50 = 8.3 µM; adenylyl cyclase type III: IC50 = 132 µM; adenylyl cyclase type II: IC50 = 1.7 mM
pK Values :
pKb: 1.85
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
2772368
MDL Number :
MFCD02026323
SMILES :
C1C(CC(=O)C2=CN=C(N=C21)N)C3=CC=CO3

Download SDS (MSDS)

Certificate of Analysis

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