Adenosine 3prime,5prime-cyclic monophosphateA second messenger and key intracellular regulator

Adenosine 3′,5′-cyclic monophosphate (CAS 60-92-4)

Adenosine 3′,5′-cyclic monophosphate | CAS 60-92-4 is rated 5.0 out of 5 by 1.
  • y_2019, m_8, d_20, h_1
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_217584, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 98ms
  • REVIEWS, PRODUCT
Synonym: cyclic AMP; cAMP
Application: A second messenger and key intracellular regulator
CAS Number: 60-92-4
Molecular Weight: 329.21
Molecular Formula: C10H12N5O6P
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Adenosine 3',5'-cyclic monophosphate (cAMP) is an important second messenger and intracellular regulator in many biological processes and, in particular, is used in intracellular signal transduction to convey the cAMP-dependent pathway. cAMP is derived from ATP and is an adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. In eukaryotic cells, cAMP function in many biochemical processes, including the regulation of glycogen, lipid and sugar metabolism. In these roles, cAMP works by activating PKA (protein kinase A). Additionally, cAMP works independently of PKA in activating calcium channels and proving a pathway for the release of growth hormone.


References

1. Taylor, S.S., et al. 1990. Annu. Rev. Biochem. 59: 971-1005. PMID: 2165385
2. Spada, A., et al. 1997. Horm. Res. 47: 235-239. PMID: 9167957
3. Daniel, P.B., et al. 1998. Annu. Rev. Nutr. 18: 353-383. PMID: 9706229
4. Chen, T.C., et al. 1998. Lab. Invest. 78: 165-174. PMID: 9484714

Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml), ether, and 1N ammonium hydroxide (50 mg/ml). Insoluble in ethanol.
Storage :
Store at 4° C
Melting Point :
260° C (lit.)(dec.)
Boiling Point :
~701.5° C at 760 mmHg (Predicted)
Density :
~2.5 g/cm3 (Predicted)
Refractive Index :
n20D 2.01 (Predicted)
Optical Activity :
α20/D -50°±2°, c = 0.7 in water
IC50 :
CNG: EC5050 = ~1 µM (human); Epac2: IC50 = 40 µM (human)
Ki Data :
Alcohol dehydrogenase: Ki= 780 µM (Equus caballus)
pK Values :
pKa: 1 (Predicted), pKb: 3.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
AU7357600
PubChem CID :
6076
Merck Index :
14: 2708
MDL Number :
MFCD00005845
EC Number :
200-492-9
Beilstein Registry :
52645
SMILES :
C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C3N=CN=C4N)O)OP(=O)(O1)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 72ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Mu oz Mu oz-Llancao, P. et al. (PubMed 26269639) observed that exchange protein directly activated by cAMP regulates neuronal polarization through Rap1B. -SCBT Publication Review
Date published: 2015-06-20
  • y_2019, m_8, d_20, h_1
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_217584, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 29ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.