ADAMTS-5 Inhibitor is a thioxothiazolidinone compound that possesses a Zn2+-chelating structural motif and acts as an ADAMTS-5 (aggrecanase-2) inhibitor (IC50 = 1.1 μM) with ~40-fold selectivity over ADAMTS-4 (aggrecanase-1).
Bursavich, M.G., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1185. Gilbert, A.M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1189.
Soluble in DMSO (10 mg/ml).
Store at -20° C
~1.6 g/cm3 (Predicted)
ADAMTS-5 : IC50 = 1.1 µM
pKa: 6.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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