Aculeacin A An amphophilic antibiotic that inhibits the biosynthesis of β-glucan

Aculeacin A (CAS 58814-86-1)

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Application: An amphophilic antibiotic that inhibits the biosynthesis of β-glucan
CAS Number: 58814-86-1
Purity: ≥95%
Molecular Weight: 1036.22
Molecular Formula: C50H81N7O16
* Refer to Certificate of Analysis for lot specific data (including water content).
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An amphophilic antibiotic with antifungal activity. The antifungal mode of action has been documented through the inhibition of β-glucagon biosythesis through selective blockage of the β-1,3-glucan synthetase reaction. This inhibition of β-1,3-glucan synthetase has also been attributed to Aculeacin A's antibiotic activity to inhibit cell wall synthesis.


References

1. Mizuno, K., et al. 1977. J. Antibiot. 30: 297-302. PMID: 324959
2. Yamaguchi, H., et al. 1982. J. Antibiot. 35: 210-219. PMID: 7042671
3. Yamaguchi, H., et al. 1985. Microbiol. Immunol. 29: 609-623. PMID: 2935715

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml), DMF, ethanol and methanol
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
AU2980000
PubChem CID :
122233
SMILES :
CCCCCCCCCCCCCCCC(=O)NC1CC(C(NC(=O)C2C(C(CN2C(=O)C(NC(=O)C(NC(=O)C3CC(CN3C(=O)C(NC1=O)C(C)O)O)C(C(C4=CC=C(C=C4)O)O)O)C(C)O)C)O)O)O

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Certificate of Analysis

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