Actinomycin D A potent antibiotic that binds to the GpC steps of DNA

Actinomycin D (CAS 50-76-0)

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Synonym: Oncostatin K; Actinomycin IV
Application: A potent antibiotic that binds to the GpC steps of DNA
CAS Number: 50-76-0
Purity: ≥98%
Molecular Weight: 1255.42
Molecular Formula: C62H86N12O16
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Actinomycin D is a metabolite isolated from Streptomyces parvulus that binds to the GpC steps of DNA. The compound acts as an antibiotic and is more effective against gram-positive bacteria than gram negative bacteria. Actinomycin D can induce apoptosis in several cell lines such as lung and prostate cancer lines, and human blood lymphocytes, among others. This compound is also an RNA polymerase inhibitor. In studies it has been observed that Actinomycin D elevates p53 expression, leading to the increase of PUMAα/β (the p53 upregulated modulator of apoptosis protein; PUMA), and can also induce tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced caspase-dependent and -independent apoptosis.


References

1. Bailey, S.A., et al. 1993. Biochemistry. 32: 5881-5887. PMID: 8504108
2. Verhaegen, S., et al. 1995. Biochem. Pharmacol. 50: 1021-1029. PMID: 7575657
3. Kalousek, I., et al. 2007. Anticancer Drugs. 18: 763-772. PMID: 17581298
4. Wang, M.J., et al. 2007. Neurosci. Res. 59: 40-46. PMID: 17707539
5. Xu, H. and Krystal, G.W. 2010. Clin Cancer Res. PMID: 20732961

Physical State :
Solid
Derived From :
Streptomyces parvulus
Solubility :
Soluble in DMSO (>20 mg/ml), 100% ethanol (1 mg/ml), methanol, chloroform, acetonitrile (9.80 - 10.20 mg/ml), and 1,2-Propanediol.
Storage :
Store at -20° C
Melting Point :
251-253° C
Boiling Point :
1386.05° C at 760 mmHg (Predicted)
Density :
1.43 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
Optical Activity :
α28/D -315°, c = 0.25 in methanol
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
AU1575000
PubChem CID :
2019
Merck Index :
14: 2800
MDL Number :
MFCD00005033
EC Number :
200-063-6
Beilstein Registry :
605235
SMILES :
CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C

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Actinomycin D  Product Citations

See how others have used Actinomycin D. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 28344040  Zhang, S. et al. 2017. Cancer Cell. 31: 591-606.e6.

PMID: # 27194299  Ni, C. et al. 2017. Mol. Neurobiol. 54: 3591-3605.

PMID: # 25492478  Friedrich, M. et al. 2015. Mucosal Immunol. 8: 943-58.

PMID: # 22312129  De Arras, L. et al. 2012. J. Immunol. 188: 2905-13.

PMID: # 12665485  Wang, CH. et al. 2003. Circulation. 107: 1783-1790.

Citations 1 to 5 of 5 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Actinomycin D, sc-200906, is in red shiny crystalline form.
Answered by: Chemical Support 4
Date published: 2017-03-28
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Rated 5 out of 5 by from great! I bought it a month ago and it works well! I treat cells with it for 12 hours.
Date published: 2016-12-29
Rated 5 out of 5 by from Worked well in application Worked well in application
Date published: 2015-10-09
Rated 5 out of 5 by from An increase in p53 protein expression was An increase in p53 protein expression was observed by WB in MOLT-4 cells post treatment with Actinomycin D. -SCBT QC
Date published: 2015-03-07
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