Acetyl-11-keto-beta-Boswellic Acid, Boswellia serrata A 5-LO and topo I and II inhibitor

Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata (CAS 67416-61-9)

Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata, CAS 67416-61-9 is rated 5.0 out of 5 by 1.
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Synonym: 3-O-Acetyl-11-keto-β-Boswellic Acid
Application: A 5-LO and topo I and II inhibitor
CAS Number: 67416-61-9
Purity: ≥98%
Molecular Weight: 512.72
Molecular Formula: C32H48O5
* Refer to Certificate of Analysis for lot specific data (including water content).

Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata is a potent non-redox, noncompetitive 5-LO (5-lipoxygenase) and Topo I and II inhibitor leading to apoptosis. Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata is 10-times more potent than 3-O-acetyl-β-boswellic acid (sc-202885). In addition, Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata shows antitumor and anti-inflammatory activities.


References

Syrovets, T., et al. 2005. J. Biol. Chem. 280, 6170. Altmann, A., et al. 2004. Br. J. Pharmacol. 141, 223. Altmann, A., et al. 2002. Biochem. Biophys. Res. Commun. 290, 185. Hoernlein, R.F., et al. 1999. J. Pharmacol. Exp. Ther. 288, 613

Physical State :
Solid
Derived From :
Boswellia serrata
Solubility :
Soluble in chloroform, alcohol, DMSO (10 mg/ml), acetone, dichloromethane, and diethyl ether.
Storage :
Store at 4° C
Boiling Point :
600.29° C at 760 mmHg (Predicted)
Density :
1.14 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
IC50 :
HL-60: IC50 = 11 µM (human); 5-LO: IC50 = 2.7 µM (human); HeLa: IC50 = 31 µM (human); PREP: IC50 = 7.89 µM (human)
pK Values :
pKa: 4.28 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
11168203
MDL Number :
MFCD03788777
SMILES :
CC1CCC2(CCC3(C(=CC(=O)C4C3(CCC5C4(CCC(C5(C)C(=O)O)OC(=O)C)C)C)C2C1C)C)C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Various publications cite the use of 5 Various publications cite the use of 5-Hydroxymethyl-2'-deoxyuridine as a marker for oxidative nucleic acid (DNA) damage. -SCBT Publication Review
Date published: 2015-01-09
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