ACEAA potent and selective agonist of the CB1 receptors

ACEA (CAS 220556-69-4)

ACEA | CAS 220556-69-4 is rated 5.0 out of 5 by 1.
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Synonym: arachidonyl-2-chloroethylamide
Application: A potent and selective agonist of the CB1 receptors
CAS Number: 220556-69-4
Purity: >96%
Molecular Weight: 365.99
Molecular Formula: C22H36ClNO
* Refer to Certificate of Analysis for lot specific data (including water content).
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ACEA (Arachidonyl-2-chloroethylamide) can bind to cannabinoid receptors (CB1) with a high affinity of Ki =1.4nM and act as a potent and selective agonist of the CB1 receptors. ACEA does not bind to the CB2 receptor. CB1 receptors are predominantly expressed in the central and peripheral nervous system. Studies show that ACEA displays vasomotor influence by acting through the channel vanilloid receptors 1 (TRPV1) found on capsaicin-sensitive afferent nerves. Research also shows that ACEA can stimulate cAMP accumulation in trigeminal ganglion (TG) neurons in a calcium and TRPV1 dependent manner.


References

1. Pertwee, R.G., et al. 1999. Curr. Med. Chem. 6: 635-664. PMID: 10469884
2. Hillard, C.J., et al. 1999. J. Pharmacol. Exp. Ther. 289: 1427-1433. PMID: 10336536
3. Franklin, A., et al. 2003. Eur. J. Pharmacol. 474: 195-198. PMID: 12921861
4. Price, T.J., et al. 2004. Br. J. Pharmacol. 141: 1118-1130. PMID: 15006899
5. Baker, C.L., et al. 2004. Br. J. Pharmacol. 142: 1361-1367. PMID: 15277316

Formulation :
a solution on methyl acetate
Physical State :
Liquid
Solubility :
Soluble in water (>250 µg/ml at 25° C), EtOH: PBS pH 7.2 (1: 3), DMF, DMSO, and ethanol (5 mg/ml).
Storage :
Store at -20° C
Boiling Point :
57° C
Refractive Index :
n20D 1.50 (Predicted)
Ki Data :
CB1 receptor : Ki= 1.4 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
1977
MDL Number :
MFCD02683581
SMILES :
CCCCCC=CCC=CCC=CCC=CCCCC(=O)NCCCl

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ACEA  Product Citations

See how others have used ACEA. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 20098669  Cencioni, MT. et al. 2010. PLoS ONE. 5: e8688.

PMID: # 10336536  Hillard, CJ. et al. 1999. J. Pharmacol. Exp. Ther. 289: 1427-1433.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Cencioni Cencioni, MT. et al. (PubMed 20098669) used ACEA, a potent and selective agonist of cannabinoid receptor CB1R, to determine if anandamide (AEA) is dependent on CB1R or CB2R for immunosuppression. Introduction of ACEA was ineffective, however CB2R antagonist SR144528 effectively blocked AEA activity. -SCBT Publication Review
Date published: 2015-03-06
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