Ac-YVAD-pNA A substrate for caspase-1 and caspase-4; cleavage is monitored colorimetrically at 405nm

Ac-YVAD-pNA (CAS 149231-66-3)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 60ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: Caspase-1 Substrate IV, Colorimetric
Application: A substrate for caspase-1 and caspase-4; cleavage is monitored colorimetrically at 405nm
CAS Number: 149231-66-3
Purity: ≥97%
Molecular Weight: 628.63
Molecular Formula: C29H36N6O10
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Ac-YVAD-pNA is a substrate for caspase-1 and caspase-4. The sequence is a modification of pro-interleukin-1β Asp-116 cleavage site for caspase-1. It is similar to Ac-YVAD-AMC but cleavage is monitored colorimetrically at 405nm.


References

1. Thornberry, N.A., et al. 1992. Nature. 356: 768-774. PMID: 1574116
2. Reiter, L.A. 1994. Int. J. Pept. Protein Res. 43: 87-86. PMID: 8138355
3. Thornberry, N.A. 1994. Meth. Enzymol. 244: 615-63. PMID: 7845238

Appearance :
Powder
Physical State :
Solid
Sequence :
Ac-Tyr-Val-Ala-Asp-pNA (pNA=p-Nitroaniline)
Solubility :
Soluble in DMSO (10 mM), and water (partly miscible).Dilute with buffer (pH 7.5).
Storage :
Store at -20° C
Boiling Point :
~1108.93° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10484117
MDL Number :
MFCD00274387
SMILES :
C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)C

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 52ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 43ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.