Ac-LEHD-AFC A fluorogenic substrate for caspase-4, caspase-5, and caspase-9

Ac-LEHD-AFC (CAS 210345-03-2)

Ac-LEHD-AFC | CAS 210345-03-2 is rated 5.0 out of 5 by 1.
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Synonym: Caspase-9 substrate (fluorogenic)
Application: A fluorogenic substrate for caspase-4, caspase-5, and caspase-9
CAS Number: 210345-03-2
Purity: ≥96%
Molecular Weight: 765.69
Molecular Formula: C33H38F3N7O11
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ac-LEHD-AFC is a fluorogenic substrate for caspase-4, caspase-5, and caspase-9.


References

1. Thornberry, N.A., et al. 1997. J. Biol. Chem. 272: 17907-17911. PMID: 9218414

Appearance :
Powder
Physical State :
Solid
Sequence :
Ac-Leu-Glu-His-Asp-AFC
Solubility :
Soluble in DMSO (20 mM), DMF (20 mM), and water (1 mg/ml).
Storage :
Store at -20° C
Boiling Point :
1211.87° C at 760 mmHg (Predicted)
Density :
1.46 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
Fluoresence :
λex 400 nm, λem 505 nm in DMSO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
44134612
MDL Number :
MFCD01862610
SMILES :
CC(C)CC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC(=O)O)C(=O)NC2=CC3=C(C=C2)C(=CC(=O)O3)C(F)(F)F)NC(=O)C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Kwon KB; et al Kwon KB; et al. (PubMed ID: 15742393) utilized Ac-LEHD-AFC to measure Caspase-3 and -9 enzyme activities in studying the anti-mutagenic and anti-cancer activities of Scorpio water extract. -SCBT Publication Review
Date published: 2015-04-18
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