Ac-IETD-AFC A substrate for caspase-8/caspase-3 processing enzyme and granzyme B

Ac-IETD-AFC (CAS 211990-57-7)

Ac-IETD-AFC | CAS 211990-57-7 is rated 5.0 out of 5 by 1.
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Synonym: Caspase-8 Substrate IETD-AFC; N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-(trifluoromethyl)coumarin
Application: A substrate for caspase-8/caspase-3 processing enzyme and granzyme B
CAS Number: 211990-57-7
Molecular Weight: 729.65
Molecular Formula: C31H38F3N5O12
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ac-IETD-AFC is a fluorogenic substrate for caspase-8/caspase-3 processing enzyme and granzyme B. It is also a substrate for caspase-10. The IETD sequence is based on caspase-3 proenzyme cleavage site.


References

1. Lazebnik, Y.A., et al. 1994. Nature. 371: 346-347. PMID: 8090205
2. Nicholson, D.W., et al. 1995. Nature 376: 37-43. PMID: 7596430
3. Thornberry, N.A. 1994. Methods Enzymol. 244: 615-63. PMID: 7845238
4. Datta, R., et al. 1997. J. Biol. Chem. 272: 1965-1969. PMID: 8999887

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO.
Storage :
Store at -20° C
Fluoresence :
λex 400 nm, λem 505 nm; λex 380 nm, λem 500 nm in DMSO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
44135098
MDL Number :
MFCD02094703
SMILES :
CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(C(C)O)C(=O)NC(CC(=O)O)C(=O)NC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F)NC(=O)C

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Certificate of Analysis

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Ac-IETD-AFC  Product Citations

See how others have used Ac-IETD-AFC. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 19118032  Trougakos, IP. et al. 2009. Clin. Cancer Res. 15: 48-59.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Weglarczyk K; et al Weglarczyk K; et al. (PubMed ID: 15102767)utilized Ac-IETD-AFC as a fluorogenic substrate to measure caspase 8 activity in cell lysates. -SCBT Publication Review
Date published: 2015-06-24
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