ABT 263 An inhibitor of antiapoptotic Bcl-2 proteins

ABT 263 (CAS 923564-51-6)

ABT 263 | CAS 923564-51-6 is rated 5.0 out of 5 by 1.
  • y_2018, m_12, d_16, h_3
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.9
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_207241, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 69ms
  • REVIEWS, PRODUCT
Synonym: Navitoclax
Application: An inhibitor of antiapoptotic Bcl-2 proteins
CAS Number: 923564-51-6
Purity: ≥98%
Molecular Weight: 974.61
Molecular Formula: C47H55ClF3N5O6S3
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

ABT 263 is a novel inhibitor of antiapoptotic BCL-2 proteins and a new promising anticancer drug candidate.


References

Adams, J., et al.: Science, 281, 1322 (1998), Degterev, A., et al.: Nat. Cell. Biol., 3, 173 (2001), Kitada, S., et al.: J. Med. Chem., 46, 4259 (2003), Danial, N., et al.: Clin. Cancer Res., 13, 7254 (2007),

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mg/ml at 25° C), chloroform, methanol, DMF (~30 mg/ml), and ethanol (~0.5 mg/ml).
Storage :
Store at -20° C
Melting Point :
114-116° C
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
Optical Activity :
α20/D -50.4°, c = 0.24 in chloroform
IC50 :
EOL1: IC50 = 6.69 nM (human); MV4-11: IC50 = 15.86 nM (human); NKM-1: IC50 = 16.99 nM (human); ML-2: IC50 = 19.83 nM (human); BV-173: IC50 = 23.14 nM (human)
Ki Data :
Bcl-2: Ki< 1 nM; Bcl-XL: Ki< 1 nM; Bcl-W: Ki< 1 nM
pK Values :
pKa: 4.6 (Predicted), pKb: 7.17 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
24978538
MDL Number :
MFCD12756219
SMILES :
CC1(C)CCC(=C(CN2CCN(CC2)C2=CC=C(C=C2)C(=O)NS(=O)(=O)C2=CC(=C(N[C@H](CCN3CCOCC3)CSC3=CC=CC=C3)C=C2)S(=O)(=O)C(F)(F)F)C1)C1=CC=C(Cl)C=C1

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

ABT 263  Product Citations

See how others have used ABT 263. Click on the entry to view the PubMed entry .

Citations 1 to 9 of 9 total

PMID: # 28414095  Waetzig, V. et al. 2017. Mol. Cell. Neurosci. 82: 12-22.

PMID: # 27030982  García, CP. et al. 2016. PLoS ONE. 11: e0152607.

PMID: # 24980820  Vasiliauskas, J. et al. 2014. Oncotarget. 5: 5547-58.

PMID: # 23234544  Sale, MJ. et al. 2013. The Biochemical journal. 450: 285-94.

PMID: # 23851982  Kiyota, M. et al. 2013. Apoptosis : an international journal on programmed cell death. 18: 1437-46.

PMID: # 23012246  Shimura, Y. et al. 2012. Molecular cancer therapeutics. 11: 2600-9.

PMID: # 22917577  Barrasa, JI. et al. 2012. Biochimica et biophysica acta. 1823: 2201-9.

PMID: # 21640157  Sasaki, N. et al. 2011. Experimental hematology. 39: 817-28.e1.

PMID: # 21424121  Jeong, NY. et al. 2011. Int. J. Oncol. 38: 1597-604.

Citations 1 to 9 of 9 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 60ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Chen et al Chen et al. (PubMed ID 26317542) used ABT 263, a Bcl-2 family inhibitor with anti-tumor properties, to induce apoptosis in human esophageal cancer cells. -SCBT Publication Review
Date published: 2015-05-02
  • y_2018, m_12, d_16, h_3
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.9
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_207241, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 215ms
  • REVIEWS, PRODUCT
--%>

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2018 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.