A 350619 hydrochlorideAn activator of soluble guanylyl cyclase

A 350619 hydrochloride (CAS 538368-27-3)

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Synonym: 3-[2-[(4-Chlorophenyl)thiophenyl]-N-[4-(dimethylamino)butyl]-2-propenamide hydrochloride
Application: An activator of soluble guanylyl cyclase
CAS Number: 538368-27-3
Molecular Weight: 425.41
Molecular Formula: C21H25ClN2OS•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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A 350619 hydrochloride is an activator of soluble guanylyl cyclase (sGC). It activates basal sGC and synergistically activates sGC in the presence of NO. It relaxes cavernosum smooth muscle in vitro and induces penile erections in rats in vivo.


References

Miller et al (2003) A-350619: a novel activator of soluble guanylyl cyclase. Life Sci. 72 1015. Evgenov et al (2006) NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat.Rev.Drug Discov. 5 755.

Physical State :
Solid
Solubility :
Soluble to 100 mM in Water
Storage :
Store at 4° C
Melting Point :
175.2-176.7° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
71433757
SMILES :
CN(C)CCCCNC(=O)C=CC1=CC=CC=C1SC2=CC=C(C=C2)Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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