9-cis-Retinoic acid is a vitamin A analog that inhibits cell proliferation and induces cell differentiation. 9-cis-Retinoic acid is an inhibitor of Cox-2 and an activator of RAR α, RAR β, RAR γ and RXR.
1. Zheng, Y. et al. 1997. Carcinogenesis. 18(11): 2119-2125. PMID: 9395211
Soluble in chloroform (50 mg/ml), DMSO (~25 mg/ml), ethanol (25 mg/ml), and acetone (25 mg/ml). Insoluble in water.
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SzabSzab , DR. et al. (PubMed 23807211) found that 9-cis-Retinoic acid, a Cox-2 inhibitor that prevents cell proliferation and induces cell differentiation, significantly decreased cell viability and steroid hormone secretion in a concentration- and time-dependent manner in the NCI-H295R cell line. -SCBT Publication Review
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