8-Bromo-cGMPA cell-permeable cGMP analog resistance to hydrolysis than cGMP

8-Bromo-cGMP (CAS 51116-01-9)

8-Bromo-cGMP | CAS 51116-01-9 is rated 5.0 out of 5 by 1.
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Synonym: 8-BR-cGMP sodium salt;8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt
Application: A cell-permeable cGMP analog resistance to hydrolysis than cGMP
CAS Number: 51116-01-9
Purity: ≥96%
Molecular Weight: 446.08
Molecular Formula: C10H10BrN5O7P•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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8-Bromo-cGMP is a cell-permeable cGMP analog with greater resistance to hydrolysis by phosphodiesterases than cGMP. The compound has been shown to preferentially activate cGKIα/β (cGMP-dependent protein kinase). In human platelets, 8-Bromo-cGMP has been found to inhibit thrombin stimulated arachidonic acid release. 8-Bromo-cGMP is known to slow or inhibit intracellular calcium oscillations of tracheal smooth muscle cells in response to acetylcholine.


References

1. Meyer, R.B., et al. 1974. Life Sci. 14: 1019-1040. PMID: 4362776
2. Schultz, K.D., et al. 1979. Naunyn Schmiedebergs Arch. Pharmacol. 306: 1-9. PMID: 218117
3. Francis, S.H., et al. 1988. Mol. Pharmacol. 34: 506-517. PMID: 2845250
4. Garg, U.C., et al. 1989. Am. J. Physiol. 257: F60-F66. PMID: 2546445
5. Sane, D.C., et al. 1989. Biochem. Biophys. Res. Commun. 165: 708-714. PMID: 2557018
6. Garg, U.C., et al. 1989. J. Clin. Invest. 83: 1774-1777. PMID: 2540223
7. Prakash, Y.S., et al. 1997. Am. J. Physiol. 272: L588-L596. PMID: 9142929
8. Choi, J., et al. 1998. J. Pharmacol. Exp. Ther. 285: 588-594. PMID: 9580602

Physical State :
Solid
Solubility :
Soluble in water (25 mg/ml) or aqueous buffers. Sparingly soluble in methanol (4mM). Insoluble in DMSO, dimethyl formamide and 96% ethanol.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
44134592
MDL Number :
MFCD00070128
EC Number :
256-993-8
SMILES :
C1C2C(C(C(O2)N3C4=C(C(=O)N=C(N4)N)N=C3Br)O)OP(=O)(O1)[O-].[Na+]

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Certificate of Analysis

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8-Bromo-cGMP  Product Citations

See how others have used 8-Bromo-cGMP. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 27092079  2016. Front Pharmacol. 7: 86.

PMID: # 25963768  Nethi, SK. et al. 2015. Nanoscale. 7: 9760-70.

PMID: # 23174781  Zhou, L. et al. 2013. Hepatology (Baltimore, Md.). 57: 1384-93.

PMID: # 7737465  Pilz, RB. et al. 1995. FASEB J. 9: 552-558.

Citations 1 to 4 of 4 total
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Rated 5 out of 5 by from Pilz et al Pilz et al. (PubMed ID 7737465) used the cGMP analog 8-Br-cGMP, to induce beta-galactosidase expression in rat thyroid cells. -SCBT Publication Review
Date published: 2015-03-23
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